Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications
Antibiotics have been the nucleus of chemotherapy since their discovery and introduction into the healthcare system in the 1940s. They are routinely used to treat bacterial infections and to prevent infections in patients with compromised immune systems and enhancing growth in livestock. However...
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Frontiers in Nanotechnology
2021
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| Online Access: | http://hdl.handle.net/20.500.12493/531 |
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| author | Keneth Iceland, Kasozi |
| author_facet | Keneth Iceland, Kasozi |
| author_sort | Keneth Iceland, Kasozi |
| collection | KAB-DR |
| description | Antibiotics have been the nucleus of chemotherapy since their discovery and introduction
into the healthcare system in the 1940s. They are routinely used to treat bacterial infections
and to prevent infections in patients with compromised immune systems and enhancing
growth in livestock. However, resistance to last-resort antibiotics used in the treatment of
multidrug-resistant infections has been reported worldwide. Therefore, this study aimed to
evaluate green synthesized nanomaterials such as silver nanoparticles (AgNPs) as
alternatives to antibiotics. UV-vis spectroscopy surface plasmon resonance peaks for
AgNPs were obtained between 417 and 475 nm. An X-ray diffraction analysis generated
four peaks for both Prunus africana extract (PAE) and Camellia sinensis extract (CSE)
biosynthesized AgNPs positioned at 2θ angles of 38.2°, 44.4°, 64.5°, and 77.4°
corresponding to crystal planes (111), (200), (220), and (311), respectively. A dynamic
light-scattering analysis registered the mean zeta potential of +6.3mV and +0.9 mV for
PAE and CSE biosynthesized nanoparticles, respectively. Fourier transform infrared
spectroscopy spectra exhibited bands corresponding to different organic functional
groups confirming the capping of AgNPs by PAE and CSE phytochemicals. Field
emission scanning electron microscopy imaging showed that AgNPs were spherical
with average size distribution ranging from 10 to 19 nm. Biosynthesized AgNPs
exhibited maximum growth inhibitory zones of 21mm with minimum inhibitory
concentration and minimum bactericidal concentration of 125 and 250 μg/ml,
respectively, against carbapenem-resistant bacteria. |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-531 |
| institution | KAB-DR |
| publishDate | 2021 |
| publisher | Frontiers in Nanotechnology |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-5312024-01-17T04:44:37Z Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications Keneth Iceland, Kasozi green synthesis, silver nanoparticles, antibiotic resistance, Prunus africana, Camellia sinensis Antibiotics have been the nucleus of chemotherapy since their discovery and introduction into the healthcare system in the 1940s. They are routinely used to treat bacterial infections and to prevent infections in patients with compromised immune systems and enhancing growth in livestock. However, resistance to last-resort antibiotics used in the treatment of multidrug-resistant infections has been reported worldwide. Therefore, this study aimed to evaluate green synthesized nanomaterials such as silver nanoparticles (AgNPs) as alternatives to antibiotics. UV-vis spectroscopy surface plasmon resonance peaks for AgNPs were obtained between 417 and 475 nm. An X-ray diffraction analysis generated four peaks for both Prunus africana extract (PAE) and Camellia sinensis extract (CSE) biosynthesized AgNPs positioned at 2θ angles of 38.2°, 44.4°, 64.5°, and 77.4° corresponding to crystal planes (111), (200), (220), and (311), respectively. A dynamic light-scattering analysis registered the mean zeta potential of +6.3mV and +0.9 mV for PAE and CSE biosynthesized nanoparticles, respectively. Fourier transform infrared spectroscopy spectra exhibited bands corresponding to different organic functional groups confirming the capping of AgNPs by PAE and CSE phytochemicals. Field emission scanning electron microscopy imaging showed that AgNPs were spherical with average size distribution ranging from 10 to 19 nm. Biosynthesized AgNPs exhibited maximum growth inhibitory zones of 21mm with minimum inhibitory concentration and minimum bactericidal concentration of 125 and 250 μg/ml, respectively, against carbapenem-resistant bacteria. Kabale University 2021-10-08T17:02:18Z 2021-10-08T17:02:18Z 2021 Article Ssekatawa K, Byarugaba DK, Kato CD, Eddie WM, Ejobi F, Nakavuma JL, Maaza M, Sackey J, Nxumalo E, Alsharif KF, Kasozi KI, El-Saber Batiha G and Kirabira JB (2021) Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications. Front. Nanotechnol. 3:697303. doi: 10.3389/fnano.2021.697303 http://hdl.handle.net/20.500.12493/531 application/pdf Frontiers in Nanotechnology |
| spellingShingle | green synthesis, silver nanoparticles, antibiotic resistance, Prunus africana, Camellia sinensis Keneth Iceland, Kasozi Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications |
| title | Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications |
| title_full | Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications |
| title_fullStr | Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications |
| title_full_unstemmed | Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications |
| title_short | Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications |
| title_sort | green strategy based synthesis of silver nanoparticles for antibacterial applications |
| topic | green synthesis, silver nanoparticles, antibiotic resistance, Prunus africana, Camellia sinensis |
| url | http://hdl.handle.net/20.500.12493/531 |
| work_keys_str_mv | AT kenethicelandkasozi greenstrategybasedsynthesisofsilvernanoparticlesforantibacterialapplications |