Lipid - Lowering Effect of a Mixture of Allium cepa bulb and Camellia sinensis Leaf Extracts in Rats fed on High fat Diet
The burden of hyperlipidemia is on the rise globally especially in many low-income countries like Uganda. Management of this metabolic disorder mainly involves dietary and behavioral therapies, which are often met with poor results as they require time and discipline from the patients. The chemother...
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African Journal of Biomedical Reasearch
2021
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| Online Access: | http://hdl.handle.net/20.500.12493/513 |
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| author | R, Kimanje K K, Ssekatawa M, . Tirwomwe Hellen, W. Kinyi |
| author_facet | R, Kimanje K K, Ssekatawa M, . Tirwomwe Hellen, W. Kinyi |
| author_sort | R, Kimanje K |
| collection | KAB-DR |
| description | The burden of hyperlipidemia is on the rise globally especially in many low-income countries like Uganda. Management of this metabolic disorder mainly involves dietary and behavioral therapies, which are often met with poor results as they require time and discipline from the patients. The chemotherapeutic options available are expensive, have many side effects and are rarely available to the average citizen. Thus, an alternative effective remedy which is readily available and cheap is needed to combat the problem of hyperlipidemia. This study sought to establish the effect of the mixture of Allium cepa extract and Camellia sinensis extract on the serum lipid profile of the male Wistar rats. Allium cepa and Camellia sinensis mixture in a ratio of 3:7 had the highest antioxidant activity. It reduced body weight, total cholesterol, triacylglycerides, LDL-cholesterol and increased HDL, and in addition it had no toxicity to the liver of the animal models used. It has thus been recommended as a potential therapy for hyperlipidemia and its associated complication of liver toxicity. A pharmaco-kinetic study regarding the interaction of antioxidants for combinations of Allium cepa and Camellia sinensis extracts in different ratios should be conducted to understand the cause of synergism and antagonism. |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-513 |
| institution | KAB-DR |
| publishDate | 2021 |
| publisher | African Journal of Biomedical Reasearch |
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| spelling | oai:idr.kab.ac.ug:20.500.12493-5132024-01-17T04:43:47Z Lipid - Lowering Effect of a Mixture of Allium cepa bulb and Camellia sinensis Leaf Extracts in Rats fed on High fat Diet R, Kimanje K K, Ssekatawa M, . Tirwomwe Hellen, W. Kinyi Allium cepa, Camellia sinensis, Antioxidant activity, Hyperlipidemia, Lipid profile, High fat diet The burden of hyperlipidemia is on the rise globally especially in many low-income countries like Uganda. Management of this metabolic disorder mainly involves dietary and behavioral therapies, which are often met with poor results as they require time and discipline from the patients. The chemotherapeutic options available are expensive, have many side effects and are rarely available to the average citizen. Thus, an alternative effective remedy which is readily available and cheap is needed to combat the problem of hyperlipidemia. This study sought to establish the effect of the mixture of Allium cepa extract and Camellia sinensis extract on the serum lipid profile of the male Wistar rats. Allium cepa and Camellia sinensis mixture in a ratio of 3:7 had the highest antioxidant activity. It reduced body weight, total cholesterol, triacylglycerides, LDL-cholesterol and increased HDL, and in addition it had no toxicity to the liver of the animal models used. It has thus been recommended as a potential therapy for hyperlipidemia and its associated complication of liver toxicity. A pharmaco-kinetic study regarding the interaction of antioxidants for combinations of Allium cepa and Camellia sinensis extracts in different ratios should be conducted to understand the cause of synergism and antagonism. Kabale University 2021-07-30T17:08:52Z 2021-07-30T17:08:52Z 2021 Article http://hdl.handle.net/20.500.12493/513 application/pdf African Journal of Biomedical Reasearch |
| spellingShingle | Allium cepa, Camellia sinensis, Antioxidant activity, Hyperlipidemia, Lipid profile, High fat diet R, Kimanje K K, Ssekatawa M, . Tirwomwe Hellen, W. Kinyi Lipid - Lowering Effect of a Mixture of Allium cepa bulb and Camellia sinensis Leaf Extracts in Rats fed on High fat Diet |
| title | Lipid - Lowering Effect of a Mixture of Allium cepa bulb and Camellia sinensis Leaf Extracts in Rats fed on High fat Diet |
| title_full | Lipid - Lowering Effect of a Mixture of Allium cepa bulb and Camellia sinensis Leaf Extracts in Rats fed on High fat Diet |
| title_fullStr | Lipid - Lowering Effect of a Mixture of Allium cepa bulb and Camellia sinensis Leaf Extracts in Rats fed on High fat Diet |
| title_full_unstemmed | Lipid - Lowering Effect of a Mixture of Allium cepa bulb and Camellia sinensis Leaf Extracts in Rats fed on High fat Diet |
| title_short | Lipid - Lowering Effect of a Mixture of Allium cepa bulb and Camellia sinensis Leaf Extracts in Rats fed on High fat Diet |
| title_sort | lipid lowering effect of a mixture of allium cepa bulb and camellia sinensis leaf extracts in rats fed on high fat diet |
| topic | Allium cepa, Camellia sinensis, Antioxidant activity, Hyperlipidemia, Lipid profile, High fat diet |
| url | http://hdl.handle.net/20.500.12493/513 |
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