Diversity of Mycobacterium tuberculosis Complex Lineages Associated with Pulmonary Tuberculosis in Southwestern, Uganda
Uganda is among the 22 countries in the world with a high burden of tuberculosis. The southwestern region of the country has consistently registered a high TB/HIV incidence rate. This study is aimed at characterizing the Mycobacterium tuberculosis complex (MTBC) genotypic diversity in southwestern...
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| Main Authors: | , , |
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| Format: | Article |
| Published: |
Hindawi
2021
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12493/512 |
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| Summary: | Uganda is among the 22 countries in the world with a high burden of tuberculosis. The southwestern region of the country has
consistently registered a high TB/HIV incidence rate. This study is aimed at characterizing the Mycobacterium tuberculosis
complex (MTBC) genotypic diversity in southwestern Uganda. A total of 283 sputum samples from patients with pulmonary
tuberculosis were genotyped using specific single nucleotide polymorphism markers for lineages 3 and 4. Most of the patients
were males with a mean age of 34. The lineage 4 Ugandan family was found to be the most dominant strains accounting for
59.7% of all cases followed by lineage 3 at 15.2%. The lineage 4 non-Ugandan family accounted for 14.5% of all cases while 4.2% showed amplification for both lineage 4 and lineage 3. Eighteen samples (6.4%) of the strains remained unclassified since they could not be matched to any lineage based on the genotyping technique used. This study demonstrates that a wide diversity of strains is causing pulmonary tuberculosis in this region with those belonging to the lineage 4 Ugandan family being more predominant. However, to confirm this, further studies using more discriminative genotyping methods are necessary. |
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