Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster
Background: The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. This research was targeted toward determining the effects of ethanolic extract of propo...
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| Format: | Article |
| Language: | en_US |
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Journal of Complementary and Integrative Medicine
2020
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| Online Access: | http://hdl.handle.net/20.500.12493/439 |
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| author | Herbert Izo, Ninsiima Emmanuel Tiyo, Ayikobua Josephine, Kasolo Keneth Iceland, Kasozi Ejike, Daniel Eze |
| author_facet | Herbert Izo, Ninsiima Emmanuel Tiyo, Ayikobua Josephine, Kasolo Keneth Iceland, Kasozi Ejike, Daniel Eze |
| author_sort | Herbert Izo, Ninsiima |
| collection | KAB-DR |
| description | Background: The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila
melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy.
This research was targeted toward determining the effects of ethanolic extract of propolis, with levodopa
therapy in the management of Parkinsonism.
Method: The PINK1B9 flies were divided into groups and fed with the different treatment doses of ethanoic
extract of propolis. The treatment groups were subjected to 21 days of administration of propolis and the levodopa
at different doses after which percentage climbing index, antioxidant activity and lifespan studies were
done.
Results: Propolis alone improved motor activity, antioxidant and lifespan in Drosophila melanogaster than in
PINK1 flies. Propolis in combination with levodopa significantly (P<0.05) improved physiological parameters
at higher than lower concentrations in Parkinsonism Drosophila melanogaster demonstrating its importance in
managing side effects associated with levodopa.
Conclusion: Propolis is a novel candidate as an alternative and integrative medicinal option to use in the management
of Parkinsonism in both animals and humans at higher concentrations. |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-439 |
| institution | KAB-DR |
| language | en_US |
| publishDate | 2020 |
| publisher | Journal of Complementary and Integrative Medicine |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-4392024-01-17T04:44:21Z Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster Herbert Izo, Ninsiima Emmanuel Tiyo, Ayikobua Josephine, Kasolo Keneth Iceland, Kasozi Ejike, Daniel Eze aging, antioxidant activity, catalase, climbing index, Drosophila melanogaster, Levodopa induced dyskinesia, lifespan, oxidative stress, Parkinson’s disease, Parkinsonism, PINK1B9, propolis Background: The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. This research was targeted toward determining the effects of ethanolic extract of propolis, with levodopa therapy in the management of Parkinsonism. Method: The PINK1B9 flies were divided into groups and fed with the different treatment doses of ethanoic extract of propolis. The treatment groups were subjected to 21 days of administration of propolis and the levodopa at different doses after which percentage climbing index, antioxidant activity and lifespan studies were done. Results: Propolis alone improved motor activity, antioxidant and lifespan in Drosophila melanogaster than in PINK1 flies. Propolis in combination with levodopa significantly (P<0.05) improved physiological parameters at higher than lower concentrations in Parkinsonism Drosophila melanogaster demonstrating its importance in managing side effects associated with levodopa. Conclusion: Propolis is a novel candidate as an alternative and integrative medicinal option to use in the management of Parkinsonism in both animals and humans at higher concentrations. Kabale University 2020-07-09T08:10:52Z 2020-07-09T08:10:52Z 2020 Article http://hdl.handle.net/20.500.12493/439 en_US application/pdf Journal of Complementary and Integrative Medicine |
| spellingShingle | aging, antioxidant activity, catalase, climbing index, Drosophila melanogaster, Levodopa induced dyskinesia, lifespan, oxidative stress, Parkinson’s disease, Parkinsonism, PINK1B9, propolis Herbert Izo, Ninsiima Emmanuel Tiyo, Ayikobua Josephine, Kasolo Keneth Iceland, Kasozi Ejike, Daniel Eze Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster |
| title | Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster |
| title_full | Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster |
| title_fullStr | Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster |
| title_full_unstemmed | Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster |
| title_short | Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster |
| title_sort | synergistic action of propolis with levodopa in the management of parkinsonism in drosophila melanogaster |
| topic | aging, antioxidant activity, catalase, climbing index, Drosophila melanogaster, Levodopa induced dyskinesia, lifespan, oxidative stress, Parkinson’s disease, Parkinsonism, PINK1B9, propolis |
| url | http://hdl.handle.net/20.500.12493/439 |
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