Cytotoxicity of isoflavones from Millettia dura
The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of...
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Taylor & Francis
2025
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| Online Access: | http://hdl.handle.net/20.500.12493/2940 |
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| author | Buyinza, Daniel Yang, Li Jun Derese, Solomon Ndakala, Albert Coghi, Paolo Heydenreich, Matthias Wong, Vincent Kam Wai Möller, Heiko M. Yenesew, Abiy |
| author_facet | Buyinza, Daniel Yang, Li Jun Derese, Solomon Ndakala, Albert Coghi, Paolo Heydenreich, Matthias Wong, Vincent Kam Wai Möller, Heiko M. Yenesew, Abiy |
| author_sort | Buyinza, Daniel |
| collection | KAB-DR |
| description | The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 lM. Durmillone was the most active with IC50 values of 6.6 lM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 ¼ 58.4 lM), LO2 hepatocytes (IC50 78.7 lM) and CCD19Lu fibroblasts (IC50 >100 lM). |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-2940 |
| institution | KAB-DR |
| language | English |
| publishDate | 2025 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-29402025-09-03T00:00:36Z Cytotoxicity of isoflavones from Millettia dura Buyinza, Daniel Yang, Li Jun Derese, Solomon Ndakala, Albert Coghi, Paolo Heydenreich, Matthias Wong, Vincent Kam Wai Möller, Heiko M. Yenesew, Abiy Millettia dura Leguminosae isoflavone cytotoxicity The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 lM. Durmillone was the most active with IC50 values of 6.6 lM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 ¼ 58.4 lM), LO2 hepatocytes (IC50 78.7 lM) and CCD19Lu fibroblasts (IC50 >100 lM). International Science Program (ISP, KEN 02) 2025-09-02T17:50:55Z 2025-09-02T17:50:55Z 2019 Article Daniel Buyinza, Li Jun Yang, Solomon Derese, Albert Ndakala, Paolo Coghi, Matthias Heydenreich, Vincent Kam Wai Wong, Heiko M. Möller & Abiy Yenesew (2019): Cytotoxicity of isoflavones from Millettia dura, Natural Product Research, DOI: 10.1080/14786419.2019.1660335 1478-6427 http://hdl.handle.net/20.500.12493/2940 en Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ application/pdf Taylor & Francis |
| spellingShingle | Millettia dura Leguminosae isoflavone cytotoxicity Buyinza, Daniel Yang, Li Jun Derese, Solomon Ndakala, Albert Coghi, Paolo Heydenreich, Matthias Wong, Vincent Kam Wai Möller, Heiko M. Yenesew, Abiy Cytotoxicity of isoflavones from Millettia dura |
| title | Cytotoxicity of isoflavones from Millettia dura |
| title_full | Cytotoxicity of isoflavones from Millettia dura |
| title_fullStr | Cytotoxicity of isoflavones from Millettia dura |
| title_full_unstemmed | Cytotoxicity of isoflavones from Millettia dura |
| title_short | Cytotoxicity of isoflavones from Millettia dura |
| title_sort | cytotoxicity of isoflavones from millettia dura |
| topic | Millettia dura Leguminosae isoflavone cytotoxicity |
| url | http://hdl.handle.net/20.500.12493/2940 |
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