Ugochukwu, Oliver Ukachi
OBJECTIVES: This study looked at how CMSO affected male Wistar albino rats' liver damage caused by bisphenol A. METHODS: The standard HPLC method was used to assess the CMSO's phenolic content. Then, six (n = 8) groups of forty-eight (48) male Wistar rats (150 20 g) each received either...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2024
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| Online Access: | http://hdl.handle.net/20.500.12493/1957 |
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| author | Maduabuchi , Patrick Aja Chukwu, Chinecherem Adanna Okechukwu, Ugwu Paul Chima Anthony, Boniface Ale Chinedu , Peter Agu Deusdedi, Tusubira Chukwu, Darlington C Onyedika, Gabriel Ani Ugbala, Ezebuilo Ekpono Akobi , Hilary Ogwoni Awoke , Joshua Nonso Ogbu, Patience N Aja, Lucy Orji, Obasi Uche Nweke, Chinoso Peter Egwu, Chinedu Ekpono, Ejike Ugbala Ewa, Gift Onyinyechi Igwenyi, Ikechuku Okorie Esther, Alum Ugo Uti, Daniel Ejim Offor, Christian Emeka Ifie, Josiah E. Njoku, Amaobichukwu Kenneth, Ekenechukwu Ejike, Daniel Eze |
| author_facet | Maduabuchi , Patrick Aja Chukwu, Chinecherem Adanna Okechukwu, Ugwu Paul Chima Anthony, Boniface Ale Chinedu , Peter Agu Deusdedi, Tusubira Chukwu, Darlington C Onyedika, Gabriel Ani Ugbala, Ezebuilo Ekpono Akobi , Hilary Ogwoni Awoke , Joshua Nonso Ogbu, Patience N Aja, Lucy Orji, Obasi Uche Nweke, Chinoso Peter Egwu, Chinedu Ekpono, Ejike Ugbala Ewa, Gift Onyinyechi Igwenyi, Ikechuku Okorie Esther, Alum Ugo Uti, Daniel Ejim Offor, Christian Emeka Ifie, Josiah E. Njoku, Amaobichukwu Kenneth, Ekenechukwu Ejike, Daniel Eze |
| author_sort | Maduabuchi , Patrick Aja |
| collection | KAB-DR |
| description | OBJECTIVES: This study looked at how CMSO affected male Wistar albino rats' liver damage
caused by bisphenol A.
METHODS: The standard HPLC method was used to assess the CMSO's phenolic content. Then, six
(n = 8) groups of forty-eight (48) male Wistar rats (150 20 g) each received either CMSO or olive oil
before being exposed to BPA for 42 days. Groups: A (one milliliter of olive oil, regardless of weight),
B (BPA 100 mg/kg body weight (BW)), C (CMSO 7.5 mg/kg BW), D (CMSO 7.5 mg/kg BW + BPA
100 mg/kg BW), E (CMSO 5.0 mg/kg BW + BPA 100 mg/kg BW), and F (CMSO 2.5 mg/kg BW +
BPA 100 mg/kg BW).
KEY FINDINGS: A surprising abundance of flavonoids, totaling 17.8006 10.95 g/100 g, were found
in the HPLC data. Malondialdehyde, liver enzymes, reactive oxygen species, total bilirubin, and direct
bilirubin levels were all significantly elevated by BPA (p 0.05). Additionally, nuclear factor-B,
interleukin-6, interleukin-1, tumor necrosis factor, and histological alterations were all considerably (p
0.05) caused by BPA. The altered biochemical markers and histology were, however, noticeably
recovered by CMSO to a level that was comparable to the control.
CONCLUSION: Due to the abundance of flavonoid components in the oil, CMSO protects the liver
from BPA-induced hepatotoxicity by lowering oxidative stress and inflammatory reactions |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-1957 |
| institution | KAB-DR |
| language | English |
| publishDate | 2024 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-19572024-08-01T00:02:45Z Ugochukwu, Oliver Ukachi Maduabuchi , Patrick Aja Chukwu, Chinecherem Adanna Okechukwu, Ugwu Paul Chima Anthony, Boniface Ale Chinedu , Peter Agu Deusdedi, Tusubira Chukwu, Darlington C Onyedika, Gabriel Ani Ugbala, Ezebuilo Ekpono Akobi , Hilary Ogwoni Awoke , Joshua Nonso Ogbu, Patience N Aja, Lucy Orji, Obasi Uche Nweke, Chinoso Peter Egwu, Chinedu Ekpono, Ejike Ugbala Ewa, Gift Onyinyechi Igwenyi, Ikechuku Okorie Esther, Alum Ugo Uti, Daniel Ejim Offor, Christian Emeka Ifie, Josiah E. Njoku, Amaobichukwu Kenneth, Ekenechukwu Ejike, Daniel Eze Bisphenol A Hepatotoxicity Oxidative stress Anti-inflammation Antioxidant Cucumeropsis mannii Flavonoids profile OBJECTIVES: This study looked at how CMSO affected male Wistar albino rats' liver damage caused by bisphenol A. METHODS: The standard HPLC method was used to assess the CMSO's phenolic content. Then, six (n = 8) groups of forty-eight (48) male Wistar rats (150 20 g) each received either CMSO or olive oil before being exposed to BPA for 42 days. Groups: A (one milliliter of olive oil, regardless of weight), B (BPA 100 mg/kg body weight (BW)), C (CMSO 7.5 mg/kg BW), D (CMSO 7.5 mg/kg BW + BPA 100 mg/kg BW), E (CMSO 5.0 mg/kg BW + BPA 100 mg/kg BW), and F (CMSO 2.5 mg/kg BW + BPA 100 mg/kg BW). KEY FINDINGS: A surprising abundance of flavonoids, totaling 17.8006 10.95 g/100 g, were found in the HPLC data. Malondialdehyde, liver enzymes, reactive oxygen species, total bilirubin, and direct bilirubin levels were all significantly elevated by BPA (p 0.05). Additionally, nuclear factor-B, interleukin-6, interleukin-1, tumor necrosis factor, and histological alterations were all considerably (p 0.05) caused by BPA. The altered biochemical markers and histology were, however, noticeably recovered by CMSO to a level that was comparable to the control. CONCLUSION: Due to the abundance of flavonoid components in the oil, CMSO protects the liver from BPA-induced hepatotoxicity by lowering oxidative stress and inflammatory reactions 2024-02-09T09:29:03Z 2024-02-09T09:29:03Z 2023-02-09 Article http://hdl.handle.net/20.500.12493/1957 en Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ application/pdf Oxford University Press |
| spellingShingle | Bisphenol A Hepatotoxicity Oxidative stress Anti-inflammation Antioxidant Cucumeropsis mannii Flavonoids profile Maduabuchi , Patrick Aja Chukwu, Chinecherem Adanna Okechukwu, Ugwu Paul Chima Anthony, Boniface Ale Chinedu , Peter Agu Deusdedi, Tusubira Chukwu, Darlington C Onyedika, Gabriel Ani Ugbala, Ezebuilo Ekpono Akobi , Hilary Ogwoni Awoke , Joshua Nonso Ogbu, Patience N Aja, Lucy Orji, Obasi Uche Nweke, Chinoso Peter Egwu, Chinedu Ekpono, Ejike Ugbala Ewa, Gift Onyinyechi Igwenyi, Ikechuku Okorie Esther, Alum Ugo Uti, Daniel Ejim Offor, Christian Emeka Ifie, Josiah E. Njoku, Amaobichukwu Kenneth, Ekenechukwu Ejike, Daniel Eze Ugochukwu, Oliver Ukachi |
| title | Ugochukwu, Oliver Ukachi |
| title_full | Ugochukwu, Oliver Ukachi |
| title_fullStr | Ugochukwu, Oliver Ukachi |
| title_full_unstemmed | Ugochukwu, Oliver Ukachi |
| title_short | Ugochukwu, Oliver Ukachi |
| title_sort | ugochukwu oliver ukachi |
| topic | Bisphenol A Hepatotoxicity Oxidative stress Anti-inflammation Antioxidant Cucumeropsis mannii Flavonoids profile |
| url | http://hdl.handle.net/20.500.12493/1957 |
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