Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents

Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and urinary tract infections are some of the opportunistic infections (OIs) which arise when the CD4 cells of the HIV/AIDS patient fall below 200 cells/mm3. HIV/AIDS infection complications include tissue damage from oral lesio...

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Main Authors: Joseph Obiezu, Chukwujekwu Ezeonwumelu, Muhammad, Ntale, Steve, Okwudili Ogbonnia, Ezera, Agwu, Julius, Kihdze Tanayen, Ahmed, Adebowale Adedeji, Okonkwo, Chukwudi Onyeka, Ambrose, Amamchukwu Akunne, Jennifer, Chibuogwu Ebosie, Frederick, Byarugaba
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Published: Scientific Research Publishing Inc. 2019
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Online Access:http://hdl.handle.net/20.500.12493/169
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author Joseph Obiezu, Chukwujekwu Ezeonwumelu
Muhammad, Ntale
Steve, Okwudili Ogbonnia
Ezera, Agwu
Julius, Kihdze Tanayen
Ahmed, Adebowale Adedeji
Okonkwo, Chukwudi Onyeka
Ambrose, Amamchukwu Akunne
Jennifer, Chibuogwu Ebosie
Frederick, Byarugaba
author_facet Joseph Obiezu, Chukwujekwu Ezeonwumelu
Muhammad, Ntale
Steve, Okwudili Ogbonnia
Ezera, Agwu
Julius, Kihdze Tanayen
Ahmed, Adebowale Adedeji
Okonkwo, Chukwudi Onyeka
Ambrose, Amamchukwu Akunne
Jennifer, Chibuogwu Ebosie
Frederick, Byarugaba
author_sort Joseph Obiezu, Chukwujekwu Ezeonwumelu
collection KAB-DR
description Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and urinary tract infections are some of the opportunistic infections (OIs) which arise when the CD4 cells of the HIV/AIDS patient fall below 200 cells/mm3. HIV/AIDS infection complications include tissue damage from oral lesions accompanied with pains. Pain is a disagreeable sensory and sensitive experience associated with actual or potential tissue damage. This condition requires immediate treatment with analgesics and antibiotics. However, the inability of rural dwellers to afford readily available drugs is a consequence for using herbs like Bidens pilosa whose local usefulness in the management of oral lesions of HIV/AIDS has not been proven scientifically. Therefore, the objective of this study was to provide the scientific basis in rats for the traditional healers’ use of Bidens pilosa leaves’ extracts in managing pain associated with oral lesions of HIV/AIDS patients in South Western Uganda. Assessment of the analgesic effects of Bidens pilosa was conducted using acetic acid in mice, formalin-induced pain and tail flick methods in rats. Both aqueous and ethanolic extracts of the leaves of Bidens pilosa produced statistically significant dose dependent inhibition of acetic acid induced pain, non dose dependent pain reduction in formalin induced pain, (p < 0.05; student t-test) and non dose dependent tail withdrawal pattern (p < 0.05, Multivariate ANOVA test). Hence, we conclude that extracts of Bidens pilosa have an analgesic basis for their local use in treatment of oral lesions associated pain in HIV/AIDS patients in South-Western Uganda.
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spelling oai:idr.kab.ac.ug:20.500.12493-1692024-01-17T04:48:20Z Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents Joseph Obiezu, Chukwujekwu Ezeonwumelu Muhammad, Ntale Steve, Okwudili Ogbonnia Ezera, Agwu Julius, Kihdze Tanayen Ahmed, Adebowale Adedeji Okonkwo, Chukwudi Onyeka Ambrose, Amamchukwu Akunne Jennifer, Chibuogwu Ebosie Frederick, Byarugaba Local Use, Bidens pilosa , Pain, Oral Lesion, HIV/AIDS, Rodents Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and urinary tract infections are some of the opportunistic infections (OIs) which arise when the CD4 cells of the HIV/AIDS patient fall below 200 cells/mm3. HIV/AIDS infection complications include tissue damage from oral lesions accompanied with pains. Pain is a disagreeable sensory and sensitive experience associated with actual or potential tissue damage. This condition requires immediate treatment with analgesics and antibiotics. However, the inability of rural dwellers to afford readily available drugs is a consequence for using herbs like Bidens pilosa whose local usefulness in the management of oral lesions of HIV/AIDS has not been proven scientifically. Therefore, the objective of this study was to provide the scientific basis in rats for the traditional healers’ use of Bidens pilosa leaves’ extracts in managing pain associated with oral lesions of HIV/AIDS patients in South Western Uganda. Assessment of the analgesic effects of Bidens pilosa was conducted using acetic acid in mice, formalin-induced pain and tail flick methods in rats. Both aqueous and ethanolic extracts of the leaves of Bidens pilosa produced statistically significant dose dependent inhibition of acetic acid induced pain, non dose dependent pain reduction in formalin induced pain, (p < 0.05; student t-test) and non dose dependent tail withdrawal pattern (p < 0.05, Multivariate ANOVA test). Hence, we conclude that extracts of Bidens pilosa have an analgesic basis for their local use in treatment of oral lesions associated pain in HIV/AIDS patients in South-Western Uganda. Kabale University 2019-06-14T09:10:41Z 2019-06-14T09:10:41Z 2018-06-29 Article Ezeonwumelu, J.O.C., Ntale, M., Ogbonnia, S.O., Agwu, E., Tanayen, J.K., Adedeji, A.A., Okonkwo, C.O., Akunne, A.A., Ebosie, J.C. and Byarugaba, F. (2018) Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents. Pharmacology & Pharmacy, 9, 175-192. http://hdl.handle.net/20.500.12493/169 ;2018, 9, 175-192 application/pdf Scientific Research Publishing Inc.
spellingShingle Local Use, Bidens pilosa , Pain, Oral Lesion, HIV/AIDS, Rodents
Joseph Obiezu, Chukwujekwu Ezeonwumelu
Muhammad, Ntale
Steve, Okwudili Ogbonnia
Ezera, Agwu
Julius, Kihdze Tanayen
Ahmed, Adebowale Adedeji
Okonkwo, Chukwudi Onyeka
Ambrose, Amamchukwu Akunne
Jennifer, Chibuogwu Ebosie
Frederick, Byarugaba
Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
title Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
title_full Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
title_fullStr Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
title_full_unstemmed Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
title_short Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
title_sort analgesic appraisal of bidens pilosa asteraceae leaf extracts used in management of oral lesion pain in hiv aids patients in rodents
topic Local Use, Bidens pilosa , Pain, Oral Lesion, HIV/AIDS, Rodents
url http://hdl.handle.net/20.500.12493/169
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