Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents
Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and urinary tract infections are some of the opportunistic infections (OIs) which arise when the CD4 cells of the HIV/AIDS patient fall below 200 cells/mm3. HIV/AIDS infection complications include tissue damage from oral lesio...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Published: |
Scientific Research Publishing Inc.
2019
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12493/169 |
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| Summary: | Oral lesions, diarrhoea, Pneumocystis carinii pneumonia, tuberculosis and
urinary tract infections are some of the opportunistic infections (OIs) which
arise when the CD4 cells of the HIV/AIDS patient fall below 200 cells/mm3.
HIV/AIDS infection complications include tissue damage from oral lesions
accompanied with pains. Pain is a disagreeable sensory and sensitive experience
associated with actual or potential tissue damage. This condition requires
immediate treatment with analgesics and antibiotics. However, the inability
of rural dwellers to afford readily available drugs is a consequence for using herbs like Bidens pilosa whose local usefulness in the management of
oral lesions of HIV/AIDS has not been proven scientifically. Therefore, the
objective of this study was to provide the scientific basis in rats for the traditional
healers’ use of Bidens pilosa leaves’ extracts in managing pain associated
with oral lesions of HIV/AIDS patients in South Western Uganda. Assessment
of the analgesic effects of Bidens pilosa was conducted using acetic
acid in mice, formalin-induced pain and tail flick methods in rats. Both
aqueous and ethanolic extracts of the leaves of Bidens pilosa produced statistically
significant dose dependent inhibition of acetic acid induced pain, non
dose dependent pain reduction in formalin induced pain, (p < 0.05; student
t-test) and non dose dependent tail withdrawal pattern (p < 0.05, Multivariate
ANOVA test). Hence, we conclude that extracts of Bidens pilosa have an
analgesic basis for their local use in treatment of oral lesions associated pain in
HIV/AIDS patients in South-Western Uganda. |
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