Etracarpidium Conophorum Extract Exhibits Anti-Fatigue Activity in Rats Via Reduced Protein Catabolism, Increased Antioxidant Status and Delayed Lactate Elevation
Thirty rats of both sexes were assigned into 5 categories of six animals apiece. Animals in the unadministered (control) group were placed on distilled water. Group 1M and Group 1F animals were administered 500 mg/kg body weight (b.w) of T. conophorum aqueous nut extract whereas animals in Group 2...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
FUDMA Journal of Sciences (FJS)
2023
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12493/1030 |
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| Summary: | Thirty rats of both sexes were assigned into 5 categories of six animals apiece. Animals in the unadministered
(control) group were placed on distilled water. Group 1M and Group 1F animals were administered 500 mg/kg
body weight (b.w) of T. conophorum aqueous nut extract whereas animals in Group 2M and Group 2F were
administered 750 mg/kg dosage of the extricate (0.5 ml) orally once daily for 32 days. Phytoconstituents present
in the extract include: saponins, flavonoids, tannins, phenols and alkaloids. The extract at 750mg/kg b.w notably
(p<0.05) raised extracellular glucose in masculine rats when matched with males that received 500 mg/kg b.w.
The 500 mg/kg dose of the extract appreciably (p<0.05) elevated BUN in both sexes, but with reduction in both
groups at 750 mg/kg b.w when juxtaposed with their respective untreated animals. The extract at 500 mg/kg
b.w increased LDH activity in male group when compared with male rats that received 750 mg/kg dose. The
750-extract dosage did not statistically (p>0.05) alter LDH activity in both sexes. The extract at 500 and
750mg/kg b.w increased the 3rd‒6th swim in male rats. Substantive (p<0.05) rise in swimming endurance time
was first noticed at the 2nd swim when matched up with the control and group treated 500 mg/kg b.w, in female
rats. Sequel to these research findings, it is hypothesized that the anti-weakness effect of T. conophorum might
be adduced to delayed increase in lactate and reduction in protein catabolism. |
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