Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals
BACKGROUND: Borassus aethiopum fruit is claimed to be used for the management of diabetes without scientific validation. OBJECTIVE: This study seeks to evaluate the antihyperglycaemic activity of ethanol fruit extract of Borassus aethiopum in alloxan-induced diabetic rats. METHODS: 36 rats were p...
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| Language: | English |
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Mediterranean Journal of Nutrition and Metabolism 15 (2022) 429–44
2023
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| Online Access: | http://hdl.handle.net/20.500.12493/1029 |
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| author | Moses Dele, Adams Ejike, Daniel Eze |
| author_facet | Moses Dele, Adams Ejike, Daniel Eze |
| author_sort | Moses Dele, Adams |
| collection | KAB-DR |
| description | BACKGROUND: Borassus aethiopum fruit is claimed to be used for the management of diabetes without scientific validation.
OBJECTIVE: This study seeks to evaluate the antihyperglycaemic activity of ethanol fruit extract of Borassus aethiopum
in alloxan-induced diabetic rats.
METHODS: 36 rats were placed in six groups (i-vi) (n = 6). Animals in group i (standard) were given 0.4 mls of distilled
water (d.w) whereas the ones assigned to group ii, iii, iv, v and vi which were induced into diabetes (by intake of 140 mg/kg
body weight [b.w] of alloxan) were also respectively given d.w, 50 mg/kg b.w of metformin, 25, 50 and 100 mg/kg b.w of
ethanol fruit extract of Borassus aethiopum, once daily for 14 days.
RESULTS: Flavonoid found in the extract (24.04 mg/ml) occurred the most with phenolic (0.35 mg/ml) being the least. While
alloxan substantially (p < 0.05) increased the levels of some biological molecules and enzyme activity, it lowered those of
others. The extract however significantly (p < 0.05) reversed all the alloxan-induced alterations, with the extract at 100 mg/kg
b.w producing figures that compared (p > 0.05) well with those of the d.w treated non-diabetic animals and metformin-treated
diabetic animals. The extract also renewed the wholeness of histological damage in the pancreas.
CONCLUSION: The bioactive agents of B. aethiopum presented antihyperglycaemic property by preventing diabetes via
reversal of alloxan-treatment alterations in the animals |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-1029 |
| institution | KAB-DR |
| language | English |
| publishDate | 2023 |
| publisher | Mediterranean Journal of Nutrition and Metabolism 15 (2022) 429–44 |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-10292024-01-17T04:50:03Z Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals Moses Dele, Adams Ejike, Daniel Eze Diabetes mellitus Borassus aethiopum insulin Arecaceae BACKGROUND: Borassus aethiopum fruit is claimed to be used for the management of diabetes without scientific validation. OBJECTIVE: This study seeks to evaluate the antihyperglycaemic activity of ethanol fruit extract of Borassus aethiopum in alloxan-induced diabetic rats. METHODS: 36 rats were placed in six groups (i-vi) (n = 6). Animals in group i (standard) were given 0.4 mls of distilled water (d.w) whereas the ones assigned to group ii, iii, iv, v and vi which were induced into diabetes (by intake of 140 mg/kg body weight [b.w] of alloxan) were also respectively given d.w, 50 mg/kg b.w of metformin, 25, 50 and 100 mg/kg b.w of ethanol fruit extract of Borassus aethiopum, once daily for 14 days. RESULTS: Flavonoid found in the extract (24.04 mg/ml) occurred the most with phenolic (0.35 mg/ml) being the least. While alloxan substantially (p < 0.05) increased the levels of some biological molecules and enzyme activity, it lowered those of others. The extract however significantly (p < 0.05) reversed all the alloxan-induced alterations, with the extract at 100 mg/kg b.w producing figures that compared (p > 0.05) well with those of the d.w treated non-diabetic animals and metformin-treated diabetic animals. The extract also renewed the wholeness of histological damage in the pancreas. CONCLUSION: The bioactive agents of B. aethiopum presented antihyperglycaemic property by preventing diabetes via reversal of alloxan-treatment alterations in the animals Kabale University 2023-02-22T09:44:49Z 2023-02-22T09:44:49Z 2022 Article http://hdl.handle.net/20.500.12493/1029 en Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ application/pdf Mediterranean Journal of Nutrition and Metabolism 15 (2022) 429–44 |
| spellingShingle | Diabetes mellitus Borassus aethiopum insulin Arecaceae Moses Dele, Adams Ejike, Daniel Eze Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals |
| title | Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals |
| title_full | Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals |
| title_fullStr | Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals |
| title_full_unstemmed | Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals |
| title_short | Borassus aethiopum (Mart.) ethanol fruit extract reverses alloxan-treatment alterations in experimental animals |
| title_sort | borassus aethiopum mart ethanol fruit extract reverses alloxan treatment alterations in experimental animals |
| topic | Diabetes mellitus Borassus aethiopum insulin Arecaceae |
| url | http://hdl.handle.net/20.500.12493/1029 |
| work_keys_str_mv | AT mosesdeleadams borassusaethiopummartethanolfruitextractreversesalloxantreatmentalterationsinexperimentalanimals AT ejikedanieleze borassusaethiopummartethanolfruitextractreversesalloxantreatmentalterationsinexperimentalanimals |