Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats
This work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime (SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with Plasmodiumberghei. Thirty female rats weighing 120-160 g were allotted into five groups (n=...
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| Language: | English |
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FUDMA Journal of Sciences (FJS)
2023
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| Online Access: | http://hdl.handle.net/20.500.12493/1022 |
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| author | Ugochukwu Vincent, Igbokwe Ejike, Daniel Eze Moses Dele, Adams Karimah Mohammed, Rabiu Iliya, Ezekiel Prisca Ojochogu, Ajeka Peace Ogechukwu, Okpara |
| author_facet | Ugochukwu Vincent, Igbokwe Ejike, Daniel Eze Moses Dele, Adams Karimah Mohammed, Rabiu Iliya, Ezekiel Prisca Ojochogu, Ajeka Peace Ogechukwu, Okpara |
| author_sort | Ugochukwu Vincent, Igbokwe |
| collection | KAB-DR |
| description | This work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime
(SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with
Plasmodiumberghei. Thirty female rats weighing 120-160 g were allotted into five groups (n=6). Group A
(negative control) were infected but not treated. Animals in Groups B–E which were infected were given
500 mg/kg body weight (BW) of malanter DS (reference antimalarial drug), 500 mg/kg BW of BL, 250
mg/kg BW each of SL and BL as well as 250 mg/kg BW each of G, PP and UPA. Treatment was done
orally once daily for 14 days after which a few related analyses were carried out. Before treatment,
parasitemia count of animals in groups B-E was substantially (p<0.05) higher when juxtaposed with group
A. AST and ALT activities was substantively (p<0.05) elevated in group B-E when matched with group A.
Plasmodium berghei induction notably (p<0.05) lowered white blood cell (WBC) and monocyte (Mono)
levels at all groups. After 7 days of treatment, the extracts and drug which appreciably (p<0.05) lowered
plasmodium count, RBC, WBC, PCV, Hb, Plat, Lymph, Mono, Granul levels did not meaningfully(p>0.05)
affect the activities of ALP, AST and ALT. After 14 days of treatment, the extracts and drug exceptionally
(p<0.05) reduced plasmodium count, WBC and ALP activity at all groups. These results give suggestive
evidence that the plant extracts either singly or combined, could be a promising anti-plasmodial candidate. |
| format | Article |
| id | oai:idr.kab.ac.ug:20.500.12493-1022 |
| institution | KAB-DR |
| language | English |
| publishDate | 2023 |
| publisher | FUDMA Journal of Sciences (FJS) |
| record_format | dspace |
| spelling | oai:idr.kab.ac.ug:20.500.12493-10222024-01-17T04:47:32Z Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats Ugochukwu Vincent, Igbokwe Ejike, Daniel Eze Moses Dele, Adams Karimah Mohammed, Rabiu Iliya, Ezekiel Prisca Ojochogu, Ajeka Peace Ogechukwu, Okpara Malaria Plasmodium berghei Vernonia amygdalina Parasitemia. This work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime (SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with Plasmodiumberghei. Thirty female rats weighing 120-160 g were allotted into five groups (n=6). Group A (negative control) were infected but not treated. Animals in Groups B–E which were infected were given 500 mg/kg body weight (BW) of malanter DS (reference antimalarial drug), 500 mg/kg BW of BL, 250 mg/kg BW each of SL and BL as well as 250 mg/kg BW each of G, PP and UPA. Treatment was done orally once daily for 14 days after which a few related analyses were carried out. Before treatment, parasitemia count of animals in groups B-E was substantially (p<0.05) higher when juxtaposed with group A. AST and ALT activities was substantively (p<0.05) elevated in group B-E when matched with group A. Plasmodium berghei induction notably (p<0.05) lowered white blood cell (WBC) and monocyte (Mono) levels at all groups. After 7 days of treatment, the extracts and drug which appreciably (p<0.05) lowered plasmodium count, RBC, WBC, PCV, Hb, Plat, Lymph, Mono, Granul levels did not meaningfully(p>0.05) affect the activities of ALP, AST and ALT. After 14 days of treatment, the extracts and drug exceptionally (p<0.05) reduced plasmodium count, WBC and ALP activity at all groups. These results give suggestive evidence that the plant extracts either singly or combined, could be a promising anti-plasmodial candidate. Kabale University 2023-02-22T09:08:39Z 2023-02-22T09:08:39Z 2021 Article SSN online: 2616-1370 http://hdl.handle.net/20.500.12493/1022 en Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ application/pdf FUDMA Journal of Sciences (FJS) |
| spellingShingle | Malaria Plasmodium berghei Vernonia amygdalina Parasitemia. Ugochukwu Vincent, Igbokwe Ejike, Daniel Eze Moses Dele, Adams Karimah Mohammed, Rabiu Iliya, Ezekiel Prisca Ojochogu, Ajeka Peace Ogechukwu, Okpara Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats |
| title | Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats |
| title_full | Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats |
| title_fullStr | Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats |
| title_full_unstemmed | Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats |
| title_short | Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats |
| title_sort | anti malarial effects of five traditional nigerian medicinal plant extracts on plasmodium berghei infected rats |
| topic | Malaria Plasmodium berghei Vernonia amygdalina Parasitemia. |
| url | http://hdl.handle.net/20.500.12493/1022 |
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