Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats
This work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime (SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with Plasmodiumberghei. Thirty female rats weighing 120-160 g were allotted into five groups (n=...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
FUDMA Journal of Sciences (FJS)
2023
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12493/1022 |
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| Summary: | This work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime
(SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with
Plasmodiumberghei. Thirty female rats weighing 120-160 g were allotted into five groups (n=6). Group A
(negative control) were infected but not treated. Animals in Groups B–E which were infected were given
500 mg/kg body weight (BW) of malanter DS (reference antimalarial drug), 500 mg/kg BW of BL, 250
mg/kg BW each of SL and BL as well as 250 mg/kg BW each of G, PP and UPA. Treatment was done
orally once daily for 14 days after which a few related analyses were carried out. Before treatment,
parasitemia count of animals in groups B-E was substantially (p<0.05) higher when juxtaposed with group
A. AST and ALT activities was substantively (p<0.05) elevated in group B-E when matched with group A.
Plasmodium berghei induction notably (p<0.05) lowered white blood cell (WBC) and monocyte (Mono)
levels at all groups. After 7 days of treatment, the extracts and drug which appreciably (p<0.05) lowered
plasmodium count, RBC, WBC, PCV, Hb, Plat, Lymph, Mono, Granul levels did not meaningfully(p>0.05)
affect the activities of ALP, AST and ALT. After 14 days of treatment, the extracts and drug exceptionally
(p<0.05) reduced plasmodium count, WBC and ALP activity at all groups. These results give suggestive
evidence that the plant extracts either singly or combined, could be a promising anti-plasmodial candidate. |
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