Mathematical modelling of mechanotransduction via RhoA signalling pathways.

We derive and simulate a mathematical model for mechanotransduction related to the Rho GTPase signalling pathway. The model addresses the bidirectional coupling between signalling processes and cell mechanics. A numerical method based on bulk-surface finite elements is proposed for the approximation...

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Bibliographic Details
Main Authors: Sofie Verhees, Chandrasekhar Venkataraman, Mariya Ptashnyk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1013305
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