No major change in vCJD agent strain after secondary transmission via blood transfusion.
<h4>Background</h4>The identification of transmission of variant Creutzfeldt-Jakob disease (vCJD) by blood transfusion has prompted investigation to establish whether there has been any alteration in the vCJD agent following this route of secondary transmission. Any increase in virulence...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-08-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002878&type=printable |
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| author | Matthew T Bishop Diane L Ritchie Robert G Will James W Ironside Mark W Head Val Thomson Moira Bruce Jean C Manson |
| author_facet | Matthew T Bishop Diane L Ritchie Robert G Will James W Ironside Mark W Head Val Thomson Moira Bruce Jean C Manson |
| author_sort | Matthew T Bishop |
| collection | DOAJ |
| description | <h4>Background</h4>The identification of transmission of variant Creutzfeldt-Jakob disease (vCJD) by blood transfusion has prompted investigation to establish whether there has been any alteration in the vCJD agent following this route of secondary transmission. Any increase in virulence or host adaptation would require a reassessment of the risk analyses relating to the possibility of a significant secondary outbreak of vCJD. Since there are likely to be carriers of the vCJD agent in the general population, there is a potential for further infection by routes such as blood transfusion or contaminated surgical instruments.<h4>Methodology</h4>We inoculated both wild-type and transgenic mice with material from the first case of transfusion associated vCJD infection.<h4>Principal findings</h4>The strain transmission properties of blood transfusion associated vCJD infection show remarkable similarities to the strain of vCJD associated with transmission from bovine spongiform encephalopathy (BSE).<h4>Conclusions</h4>Although it has been hypothesized that adaptation of the BSE agent through secondary passage in humans may result in a greater risk of onward transmission due to an increased virulence of the agent for humans, our data presented here in two murine models suggest no significant alterations to transmission efficiency of the agent following human-to-human transmission of vCJD. |
| format | Article |
| id | doaj-art-fffd7e9df0d048c5926a67f0169f3cf0 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2008-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-fffd7e9df0d048c5926a67f0169f3cf02025-08-20T02:38:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-08-0138e287810.1371/journal.pone.0002878No major change in vCJD agent strain after secondary transmission via blood transfusion.Matthew T BishopDiane L RitchieRobert G WillJames W IronsideMark W HeadVal ThomsonMoira BruceJean C Manson<h4>Background</h4>The identification of transmission of variant Creutzfeldt-Jakob disease (vCJD) by blood transfusion has prompted investigation to establish whether there has been any alteration in the vCJD agent following this route of secondary transmission. Any increase in virulence or host adaptation would require a reassessment of the risk analyses relating to the possibility of a significant secondary outbreak of vCJD. Since there are likely to be carriers of the vCJD agent in the general population, there is a potential for further infection by routes such as blood transfusion or contaminated surgical instruments.<h4>Methodology</h4>We inoculated both wild-type and transgenic mice with material from the first case of transfusion associated vCJD infection.<h4>Principal findings</h4>The strain transmission properties of blood transfusion associated vCJD infection show remarkable similarities to the strain of vCJD associated with transmission from bovine spongiform encephalopathy (BSE).<h4>Conclusions</h4>Although it has been hypothesized that adaptation of the BSE agent through secondary passage in humans may result in a greater risk of onward transmission due to an increased virulence of the agent for humans, our data presented here in two murine models suggest no significant alterations to transmission efficiency of the agent following human-to-human transmission of vCJD.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002878&type=printable |
| spellingShingle | Matthew T Bishop Diane L Ritchie Robert G Will James W Ironside Mark W Head Val Thomson Moira Bruce Jean C Manson No major change in vCJD agent strain after secondary transmission via blood transfusion. PLoS ONE |
| title | No major change in vCJD agent strain after secondary transmission via blood transfusion. |
| title_full | No major change in vCJD agent strain after secondary transmission via blood transfusion. |
| title_fullStr | No major change in vCJD agent strain after secondary transmission via blood transfusion. |
| title_full_unstemmed | No major change in vCJD agent strain after secondary transmission via blood transfusion. |
| title_short | No major change in vCJD agent strain after secondary transmission via blood transfusion. |
| title_sort | no major change in vcjd agent strain after secondary transmission via blood transfusion |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002878&type=printable |
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