Single nuclei RNA-sequencing unveils alveolar macrophages as drivers of endothelial damage in obese HFpEF-related pulmonary hypertension

Single nuclei RNA-sequencing unveils alveolar macrophages as drivers of endothelial damage in obese HFpEF-related pulmonary hypertension

Abstract Background Pulmonary hypertension (PH) is a frequent complication in obese patients showing heart failure with preserved ejection fraction (HFpEF) and correlates with poor prognosis. PH associated with cardiometabolic HFpEF (PH-cHFpEF) is characterized by inflammation and metabolic dysregul...

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Bibliographic Details
Main Authors: Era Gorica, Jacopo Spezzini, Iliana Papadopoulou, Marialucia Telesca, Valeria Masciovecchio, Shafeeq A. Moahmmed, Alessandro Mengozzi, Hung-Wei Cheng, Natalia Atzemian, Ludovica Di Venanzio, Alessia Mongelli, Omer Dzemali, Vincenzo Calderone, Francesco Paneni, Christian M. Matter, Burkhard Ludewig, Frank Ruschitzka, Sarah Costantino
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cardiovascular Diabetology
Subjects:
PH
cHFpEF
Alveolar macrophages
Inflammation
Endothelial damage
Online Access:https://doi.org/10.1186/s12933-025-02772-y
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