Gluten and its relationship with inflammation and Parkinson's Disease: A literature review
Parkinson's Disease is a neurodegenerative central nervous system (CNS) disease that primarily affects the dopaminergic cells of the Substantia Nigra in the midbrain and causes a diverse array of symptoms, including dystonia, a loss of balance, difficulty initiating movements, akinesia, muscle...
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| Format: | Article |
| Language: | English |
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AIMS Press
2025-03-01
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| Series: | AIMS Neuroscience |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/Neuroscience.2025004 |
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| author | Zohaer Muttalib Dana Aboukhalil Chisom Nwosu Dave D. Manguerra Jimmy Wen Ubaid Ansari Meraj Alam Ihab Abed Ethan Tabaie Ahmed Salem Forshing Lui |
| author_facet | Zohaer Muttalib Dana Aboukhalil Chisom Nwosu Dave D. Manguerra Jimmy Wen Ubaid Ansari Meraj Alam Ihab Abed Ethan Tabaie Ahmed Salem Forshing Lui |
| author_sort | Zohaer Muttalib |
| collection | DOAJ |
| description | Parkinson's Disease is a neurodegenerative central nervous system (CNS) disease that primarily affects the dopaminergic cells of the Substantia Nigra in the midbrain and causes a diverse array of symptoms, including dystonia, a loss of balance, difficulty initiating movements, akinesia, muscle spasms, and tremors. It has long been known that environmental and commercial compounds are linked to an increased risk of Parkinson's Disease. Of importance, gluten, a complex polysaccharide, has been hypothesized to cause some of the symptoms related to Parkinson's Disease. It is hypothesized that gluten causes a chronic inflammatory state which may lead to plaque formation and neuronal cell death in the substantia nigra, alongside the symptoms of Parkinson's Disease. This literature review hopes to explore the relationship gluten has as an inflammatory molecule and its role in the production and prolongation of the disease processes in Parkinson's Disease. |
| format | Article |
| id | doaj-art-fff7bfa2625b45cda4d19c92dfb31794 |
| institution | Kabale University |
| issn | 2373-7972 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Neuroscience |
| spelling | doaj-art-fff7bfa2625b45cda4d19c92dfb317942025-08-20T03:48:19ZengAIMS PressAIMS Neuroscience2373-79722025-03-01121445710.3934/Neuroscience.2025004Gluten and its relationship with inflammation and Parkinson's Disease: A literature reviewZohaer Muttalib0Dana Aboukhalil1Chisom Nwosu2Dave D. Manguerra3Jimmy Wen4Ubaid Ansari5Meraj Alam6Ihab Abed7Ethan Tabaie8Ahmed Salem9Forshing Lui10Department of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USADepartment of Neurology, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USAParkinson's Disease is a neurodegenerative central nervous system (CNS) disease that primarily affects the dopaminergic cells of the Substantia Nigra in the midbrain and causes a diverse array of symptoms, including dystonia, a loss of balance, difficulty initiating movements, akinesia, muscle spasms, and tremors. It has long been known that environmental and commercial compounds are linked to an increased risk of Parkinson's Disease. Of importance, gluten, a complex polysaccharide, has been hypothesized to cause some of the symptoms related to Parkinson's Disease. It is hypothesized that gluten causes a chronic inflammatory state which may lead to plaque formation and neuronal cell death in the substantia nigra, alongside the symptoms of Parkinson's Disease. This literature review hopes to explore the relationship gluten has as an inflammatory molecule and its role in the production and prolongation of the disease processes in Parkinson's Disease.https://www.aimspress.com/article/doi/10.3934/Neuroscience.2025004parkinson's diseasegluteninflammationdystoniadyskinesiasubstantia nigra |
| spellingShingle | Zohaer Muttalib Dana Aboukhalil Chisom Nwosu Dave D. Manguerra Jimmy Wen Ubaid Ansari Meraj Alam Ihab Abed Ethan Tabaie Ahmed Salem Forshing Lui Gluten and its relationship with inflammation and Parkinson's Disease: A literature review AIMS Neuroscience parkinson's disease gluten inflammation dystonia dyskinesia substantia nigra |
| title | Gluten and its relationship with inflammation and Parkinson's Disease: A literature review |
| title_full | Gluten and its relationship with inflammation and Parkinson's Disease: A literature review |
| title_fullStr | Gluten and its relationship with inflammation and Parkinson's Disease: A literature review |
| title_full_unstemmed | Gluten and its relationship with inflammation and Parkinson's Disease: A literature review |
| title_short | Gluten and its relationship with inflammation and Parkinson's Disease: A literature review |
| title_sort | gluten and its relationship with inflammation and parkinson s disease a literature review |
| topic | parkinson's disease gluten inflammation dystonia dyskinesia substantia nigra |
| url | https://www.aimspress.com/article/doi/10.3934/Neuroscience.2025004 |
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