Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions
Background. Peptidergic GPCR systems are broadly distributed in the human body and regulate numerous physiological processes by activating complex networks of intracellular biochemical events responsible for cell regulation and survival. Excessive stimulation, ill-function, or blockade of GPCRs prod...
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MDPI AG
2024-11-01
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| Series: | Future Pharmacology |
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| author | Francisco David Rodríguez Rafael Coveñas |
| author_facet | Francisco David Rodríguez Rafael Coveñas |
| author_sort | Francisco David Rodríguez |
| collection | DOAJ |
| description | Background. Peptidergic GPCR systems are broadly distributed in the human body and regulate numerous physiological processes by activating complex networks of intracellular biochemical events responsible for cell regulation and survival. Excessive stimulation, ill-function, or blockade of GPCRs produces cell disturbances that may cause disease should compensatory mechanisms not suffice. Methods and Results. Revision of updated experimental research provided an evident relationship associating peptidergic GPCR malfunction with tumor formation and maintenance resulting from uncontrolled cell proliferation and migration, colonization, inhibition of apoptosis or altered metabolism, and increased angiogenesis in tumoral tissues. Conclusion. Determination of the implication of GPCR peptide signaling in specific neoplasia is crucial to designing tailored pharmacological treatments to counteract or dismantle the origin of the signaling circuitry causing cellular disruption. In some cases, particular ligands for these receptors may serve as concomitant treatments to aid other pharmacological or physical approaches to eradicate neoplasias. |
| format | Article |
| id | doaj-art-fff4ba755b8f4fcd9c4011965a0ae00f |
| institution | OA Journals |
| issn | 2673-9879 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj-art-fff4ba755b8f4fcd9c4011965a0ae00f2025-08-20T02:00:33ZengMDPI AGFuture Pharmacology2673-98792024-11-014480182410.3390/futurepharmacol4040043Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological SolutionsFrancisco David Rodríguez0Rafael Coveñas1Department of Biochemistry and Molecular Biology, Faculty of Chemical Sciences, University of Salamanca, 37007 Salamanca, SpainGroup GIR USAL—BMD (Bases Moleculares del Desarrollo), University of Salamanca, 37007 Salamanca, SpainBackground. Peptidergic GPCR systems are broadly distributed in the human body and regulate numerous physiological processes by activating complex networks of intracellular biochemical events responsible for cell regulation and survival. Excessive stimulation, ill-function, or blockade of GPCRs produces cell disturbances that may cause disease should compensatory mechanisms not suffice. Methods and Results. Revision of updated experimental research provided an evident relationship associating peptidergic GPCR malfunction with tumor formation and maintenance resulting from uncontrolled cell proliferation and migration, colonization, inhibition of apoptosis or altered metabolism, and increased angiogenesis in tumoral tissues. Conclusion. Determination of the implication of GPCR peptide signaling in specific neoplasia is crucial to designing tailored pharmacological treatments to counteract or dismantle the origin of the signaling circuitry causing cellular disruption. In some cases, particular ligands for these receptors may serve as concomitant treatments to aid other pharmacological or physical approaches to eradicate neoplasias.https://www.mdpi.com/2673-9879/4/4/43G-protein-coupled receptors (GPCR)peptidecell growthapoptosispeptide antagonistspeptide signaling pathways |
| spellingShingle | Francisco David Rodríguez Rafael Coveñas Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions Future Pharmacology G-protein-coupled receptors (GPCR) peptide cell growth apoptosis peptide antagonists peptide signaling pathways |
| title | Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions |
| title_full | Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions |
| title_fullStr | Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions |
| title_full_unstemmed | Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions |
| title_short | Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological Solutions |
| title_sort | peptidergic g protein coupled receptor signaling systems in cancer examination of receptor structure and signaling to foster innovative pharmacological solutions |
| topic | G-protein-coupled receptors (GPCR) peptide cell growth apoptosis peptide antagonists peptide signaling pathways |
| url | https://www.mdpi.com/2673-9879/4/4/43 |
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