Clinical features and factors associated with short-term prognosis in patients with pulmonary embolism

The aim – to study the clinical, anamnestic and instrumental parameters associated with short-term prognosis in patients with pulmonary embolism (PE). Materials and methods. This study was conducted from September 1, 2019 to December 31, 2020 on the basis of the city clinical hospital. The prelim...

Full description

Saved in:
Bibliographic Details
Main Authors: V.Y. Tseluyko, L.M. Yakovleva, S.M. Sukhova, O.V. Radchenko, T.V. Pylova, A.S. Vnukova, K.Yu. Kinoshenko
Format: Article
Language:English
Published: TOV Chetverta Khvylia 2021-07-01
Series:Кардіохірургія та інтервенційна кардіологія
Subjects:
Online Access:http://www.csic.com.ua/images/pdf/2021/2-2021/clinical-features-and-factors-associated-with-short-term-prognosisin-patients-with-pulmonary-embolism.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832570180575690752
author V.Y. Tseluyko
L.M. Yakovleva
S.M. Sukhova
O.V. Radchenko
T.V. Pylova
A.S. Vnukova
K.Yu. Kinoshenko
author_facet V.Y. Tseluyko
L.M. Yakovleva
S.M. Sukhova
O.V. Radchenko
T.V. Pylova
A.S. Vnukova
K.Yu. Kinoshenko
author_sort V.Y. Tseluyko
collection DOAJ
description The aim – to study the clinical, anamnestic and instrumental parameters associated with short-term prognosis in patients with pulmonary embolism (PE). Materials and methods. This study was conducted from September 1, 2019 to December 31, 2020 on the basis of the city clinical hospital. The preliminary analysis included 187 patients with acute pulmonary embolism. The study found that 25 (13.3 %) patients died within 30 days (group I): 19 (76.0 %) patients belonged to a high risk of predicted early death and 6 (24.0 %) – to intermediate-high risk. For further analysis, a comparison group (group II) was formed and included 106 (56.7 %) patients who survived within 30 days of the onset of an acute episode of PE: 54 (50.9 %) patients belonged to high risk, 52 (49.1 %) – to intermediate high risk. All patients with pulmonary embolism received anticoagulant therapy according to the current ESC guidelines. Results. The average age of patients in group I was 69.08 ± 14.15 years and was significantly higher than in group II: 65.25 ± 13.29 (p = 0.0169). The proportion of high-risk patients was significantly greater in the І group, the proportion of patients of intermediate-high risk was significantly greater in group II (p = 0.0409). The incidence of classes IV and V according to the PESI index, assessed in patients of intermediate-high risk, was the same in both groups, while patients with the PESI index class III prevailed in group II (p = 0.0380). The risk factors for venous thromboembolism occurred more frequently in patients of group I, i.e. congestive heart failure (p = 0.0065) and obesity (p = 0.0482). Conclusions. There is a high mortality rate within 30 days (13.3 %) in hospitalized patients with acute PE, including 26 % of high-risk patients and 10.3 % of intermediate-high risk. Age over 65 years, the presence of congestive heart failure and obesity are independent factors that, according to uni- and multivariate logistic regression analysis, are associated with poor short-term prognosis in patients with PE.
format Article
id doaj-art-fff2fddf364f43b1b54dd9ce028557b6
institution Kabale University
issn 2305-3127
language English
publishDate 2021-07-01
publisher TOV Chetverta Khvylia
record_format Article
series Кардіохірургія та інтервенційна кардіологія
spelling doaj-art-fff2fddf364f43b1b54dd9ce028557b62025-02-02T16:35:29ZengTOV Chetverta KhvyliaКардіохірургія та інтервенційна кардіологія2305-31272021-07-012182610.31928/2305-3127-2021.2.1826Clinical features and factors associated with short-term prognosis in patients with pulmonary embolismV.Y. Tseluyko0L.M. Yakovleva1S.M. Sukhova2O.V. Radchenko3T.V. Pylova4A.S. Vnukova5K.Yu. Kinoshenko6Kharkiv Medical Academy of Postgraduate Education, Kharkiv, UkraineKharkiv Medical Academy of Postgraduate Education, Kharkiv, UkraineCity Clinical Hospital # 8, Kharkiv, UkraineKharkiv Medical Academy of Postgraduate Education, Kharkiv, UkraineKharkiv Medical Academy of Postgraduate Education, Kharkiv, UkraineCity Clinical Hospital # 8, Kharkiv, UkraineKharkiv Medical Academy of Postgraduate Education, Kharkiv, UkraineThe aim – to study the clinical, anamnestic and instrumental parameters associated with short-term prognosis in patients with pulmonary embolism (PE). Materials and methods. This study was conducted from September 1, 2019 to December 31, 2020 on the basis of the city clinical hospital. The preliminary analysis included 187 patients with acute pulmonary embolism. The study found that 25 (13.3 %) patients died within 30 days (group I): 19 (76.0 %) patients belonged to a high risk of predicted early death and 6 (24.0 %) – to intermediate-high risk. For further analysis, a comparison group (group II) was formed and included 106 (56.7 %) patients who survived within 30 days of the onset of an acute episode of PE: 54 (50.9 %) patients belonged to high risk, 52 (49.1 %) – to intermediate high risk. All patients with pulmonary embolism received anticoagulant therapy according to the current ESC guidelines. Results. The average age of patients in group I was 69.08 ± 14.15 years and was significantly higher than in group II: 65.25 ± 13.29 (p = 0.0169). The proportion of high-risk patients was significantly greater in the І group, the proportion of patients of intermediate-high risk was significantly greater in group II (p = 0.0409). The incidence of classes IV and V according to the PESI index, assessed in patients of intermediate-high risk, was the same in both groups, while patients with the PESI index class III prevailed in group II (p = 0.0380). The risk factors for venous thromboembolism occurred more frequently in patients of group I, i.e. congestive heart failure (p = 0.0065) and obesity (p = 0.0482). Conclusions. There is a high mortality rate within 30 days (13.3 %) in hospitalized patients with acute PE, including 26 % of high-risk patients and 10.3 % of intermediate-high risk. Age over 65 years, the presence of congestive heart failure and obesity are independent factors that, according to uni- and multivariate logistic regression analysis, are associated with poor short-term prognosis in patients with PE.http://www.csic.com.ua/images/pdf/2021/2-2021/clinical-features-and-factors-associated-with-short-term-prognosisin-patients-with-pulmonary-embolism.pdfpulmonary embolismvenous thromboembolismshort-term prognosis
spellingShingle V.Y. Tseluyko
L.M. Yakovleva
S.M. Sukhova
O.V. Radchenko
T.V. Pylova
A.S. Vnukova
K.Yu. Kinoshenko
Clinical features and factors associated with short-term prognosis in patients with pulmonary embolism
Кардіохірургія та інтервенційна кардіологія
pulmonary embolism
venous thromboembolism
short-term prognosis
title Clinical features and factors associated with short-term prognosis in patients with pulmonary embolism
title_full Clinical features and factors associated with short-term prognosis in patients with pulmonary embolism
title_fullStr Clinical features and factors associated with short-term prognosis in patients with pulmonary embolism
title_full_unstemmed Clinical features and factors associated with short-term prognosis in patients with pulmonary embolism
title_short Clinical features and factors associated with short-term prognosis in patients with pulmonary embolism
title_sort clinical features and factors associated with short term prognosis in patients with pulmonary embolism
topic pulmonary embolism
venous thromboembolism
short-term prognosis
url http://www.csic.com.ua/images/pdf/2021/2-2021/clinical-features-and-factors-associated-with-short-term-prognosisin-patients-with-pulmonary-embolism.pdf
work_keys_str_mv AT vytseluyko clinicalfeaturesandfactorsassociatedwithshorttermprognosisinpatientswithpulmonaryembolism
AT lmyakovleva clinicalfeaturesandfactorsassociatedwithshorttermprognosisinpatientswithpulmonaryembolism
AT smsukhova clinicalfeaturesandfactorsassociatedwithshorttermprognosisinpatientswithpulmonaryembolism
AT ovradchenko clinicalfeaturesandfactorsassociatedwithshorttermprognosisinpatientswithpulmonaryembolism
AT tvpylova clinicalfeaturesandfactorsassociatedwithshorttermprognosisinpatientswithpulmonaryembolism
AT asvnukova clinicalfeaturesandfactorsassociatedwithshorttermprognosisinpatientswithpulmonaryembolism
AT kyukinoshenko clinicalfeaturesandfactorsassociatedwithshorttermprognosisinpatientswithpulmonaryembolism