Clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non-valvular atrial fibrillation
BackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia in adults and is associated with significant morbidity and mortality. Mitral stenosis (MS) is common in developing countries, affecting the younger population and posing a risk of atrial fibrillation.ObjectivesThis study aims...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1555557/full |
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| author | Mohamed Aboelhassan Hosam Hasan-Ali Mohammed Taha Mohammed Amr Ashry Mohamed Aboel-Kassem F. Abdelmegid |
| author_facet | Mohamed Aboelhassan Hosam Hasan-Ali Mohammed Taha Mohammed Amr Ashry Mohamed Aboel-Kassem F. Abdelmegid |
| author_sort | Mohamed Aboelhassan |
| collection | DOAJ |
| description | BackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia in adults and is associated with significant morbidity and mortality. Mitral stenosis (MS) is common in developing countries, affecting the younger population and posing a risk of atrial fibrillation.ObjectivesThis study aims to delineate the clinical characteristics and poor outcomes in patients who have recent non-valvular AF (NVAF) compared with AF related to MS (MS-AF). Furthermore, it seeks to assess the healthcare resource utilization associated with the management of AF patients in the two groups.Patients and methodsThis is a prospective observational cohort conducted on 84 patients with recent AF. The patients were divided into two groups: the NVAF group (patients with no prosthetic valves or moderate/severe MS) and the MS-AF group (patients with AF in the presence of moderate/severe MS). The clinical characteristics, stroke risk, and anticoagulation regimens were assessed. AF-related outcomes (strokes, hospitalizations, major bleeding, and mortalities) were monitored and compared between the two groups.ResultsThe mean age of the studied AF patients was 49.80 ± 16.31 years, ranging from 25 to 89 years. Patients with MS-AF were significantly younger than patients with NVAF. Hypertension was the most prevalent risk factor associated with AF. Smoking, heart failure, and hypertension were more prevalent among patients with NVAF. The NVAF group received less anticoagulants than the MS-AF group. There were no statistically significant differences between the two groups regarding the overall incidence of death, stroke, myocardial infarction, TIA, or hospital admissions. In the overall studied group, all-cause mortality was higher among AF patients with a history of heart failure or stroke.ConclusionPatients with NVAF had a significantly greater incidence of cardiovascular disease risk factors. However, AF related to mitral stenosis was associated with comparable worse outcomes. |
| format | Article |
| id | doaj-art-fff037c6ab2a443d8bb6c78fac1dac22 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-fff037c6ab2a443d8bb6c78fac1dac222025-08-20T02:07:47ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-06-011210.3389/fcvm.2025.15555571555557Clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non-valvular atrial fibrillationMohamed Aboelhassan0Hosam Hasan-Ali1Mohammed Taha Mohammed2Amr Ashry3Mohamed Aboel-Kassem F. Abdelmegid4Department of Cardiology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Cardiology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Cardiology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Cardiothoracic Surgery, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Cardiology, Faculty of Medicine, Assiut University, Assiut, EgyptBackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia in adults and is associated with significant morbidity and mortality. Mitral stenosis (MS) is common in developing countries, affecting the younger population and posing a risk of atrial fibrillation.ObjectivesThis study aims to delineate the clinical characteristics and poor outcomes in patients who have recent non-valvular AF (NVAF) compared with AF related to MS (MS-AF). Furthermore, it seeks to assess the healthcare resource utilization associated with the management of AF patients in the two groups.Patients and methodsThis is a prospective observational cohort conducted on 84 patients with recent AF. The patients were divided into two groups: the NVAF group (patients with no prosthetic valves or moderate/severe MS) and the MS-AF group (patients with AF in the presence of moderate/severe MS). The clinical characteristics, stroke risk, and anticoagulation regimens were assessed. AF-related outcomes (strokes, hospitalizations, major bleeding, and mortalities) were monitored and compared between the two groups.ResultsThe mean age of the studied AF patients was 49.80 ± 16.31 years, ranging from 25 to 89 years. Patients with MS-AF were significantly younger than patients with NVAF. Hypertension was the most prevalent risk factor associated with AF. Smoking, heart failure, and hypertension were more prevalent among patients with NVAF. The NVAF group received less anticoagulants than the MS-AF group. There were no statistically significant differences between the two groups regarding the overall incidence of death, stroke, myocardial infarction, TIA, or hospital admissions. In the overall studied group, all-cause mortality was higher among AF patients with a history of heart failure or stroke.ConclusionPatients with NVAF had a significantly greater incidence of cardiovascular disease risk factors. However, AF related to mitral stenosis was associated with comparable worse outcomes.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1555557/fullmitral stenosisatrial fibrillationnon-valvular atrial fibrillationNVAFrheumatic heart disease |
| spellingShingle | Mohamed Aboelhassan Hosam Hasan-Ali Mohammed Taha Mohammed Amr Ashry Mohamed Aboel-Kassem F. Abdelmegid Clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non-valvular atrial fibrillation Frontiers in Cardiovascular Medicine mitral stenosis atrial fibrillation non-valvular atrial fibrillation NVAF rheumatic heart disease |
| title | Clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non-valvular atrial fibrillation |
| title_full | Clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non-valvular atrial fibrillation |
| title_fullStr | Clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non-valvular atrial fibrillation |
| title_full_unstemmed | Clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non-valvular atrial fibrillation |
| title_short | Clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non-valvular atrial fibrillation |
| title_sort | clinical outcomes in recently diagnosed atrial fibrillation related to mitral stenosis compared to non valvular atrial fibrillation |
| topic | mitral stenosis atrial fibrillation non-valvular atrial fibrillation NVAF rheumatic heart disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1555557/full |
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