Urine amino acid and gamma aminobutyric acid level in COVID 19 patients
Background and Objectives: SARS CoV2 has tropism for various tissues, including the respiratory tract, brain, endothelium, heart, kidney and liver. Neurological symptoms can also be seen in the clinical course of the disease, and anosmia is the most common. The main objective of our study was to ex...
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Tehran University of Medical Sciences
2025-02-01
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| Series: | Iranian Journal of Microbiology |
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| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/5180 |
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| author | Cemal Kazezoglu Arzu İrvem Yasemin Tuba Sutasir Büşra Çakiroglu Banu Kirgiz Habip Yilmaz Ali Kocatas |
| author_facet | Cemal Kazezoglu Arzu İrvem Yasemin Tuba Sutasir Büşra Çakiroglu Banu Kirgiz Habip Yilmaz Ali Kocatas |
| author_sort | Cemal Kazezoglu |
| collection | DOAJ |
| description |
Background and Objectives: SARS CoV2 has tropism for various tissues, including the respiratory tract, brain, endothelium, heart, kidney and liver. Neurological symptoms can also be seen in the clinical course of the disease, and anosmia is the most common. The main objective of our study was to examine the urinary amino acid profiles of moderately severe patients diagnosed with COVID-19 with a positive RT-PCR test and try to find metabolic changes associated with the infection. Also, it was aimed to investigate the neuroinhibitory Gamma-Aminobutyric acid (GABA) levels in order to examine the physiopathology.
Materials and Methods: Thirty adult cases who were followed up in the infection clinic with positive SARS CoV 2 RT-PCR and diagnosed with COVID 19 disease were included in the study with consent. The amino acid profile of these patients' urine samples, 30 different amino acid levels and creatine levels were examined using the liquid chromatography-mass spectrometry (LCMS) method on the SCIEX QTRAP 4500 device.
Results: The mean age of the patients is 40 ± 5. Elevated GABA in 28/30 cases, high hydroxylysine amino acid in 27/30 cases, low glycine in 30/30 cases were detected in the urine. The creatinine levels of the patients were found to be normal.
Conclusion: It has been thought that the height of GABA may be due to bacteria producing GABA as a result of the change in microbiota due to lactic acidosis, as well as that the virus may directly affect the brain and cause an increase in GABA.
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| format | Article |
| id | doaj-art-ffef604dff464639b6b525a02b7eeab8 |
| institution | Kabale University |
| issn | 2008-3289 2008-4447 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj-art-ffef604dff464639b6b525a02b7eeab82025-02-09T09:01:25ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472025-02-01171Urine amino acid and gamma aminobutyric acid level in COVID 19 patientsCemal Kazezoglu0Arzu İrvem1Yasemin Tuba Sutasir2Büşra Çakiroglu3Banu Kirgiz4Habip Yilmaz5Ali Kocatas6Department of Medical Biochemistry, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, TurkeyDepartment of Medical Microbiology, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, TurkeyDepartment of Medical Biochemistry, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, TurkeyDepartment of İnfection Diseases, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, TurkeyDepartment of Medical Biochemistry, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, TurkeyDepartment of Anesthesiology and Reanimation, BakırKoy Sadi Konuk Research and Training Hospital, Istanbul, TurkeyDepartment of General Surgery, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey Background and Objectives: SARS CoV2 has tropism for various tissues, including the respiratory tract, brain, endothelium, heart, kidney and liver. Neurological symptoms can also be seen in the clinical course of the disease, and anosmia is the most common. The main objective of our study was to examine the urinary amino acid profiles of moderately severe patients diagnosed with COVID-19 with a positive RT-PCR test and try to find metabolic changes associated with the infection. Also, it was aimed to investigate the neuroinhibitory Gamma-Aminobutyric acid (GABA) levels in order to examine the physiopathology. Materials and Methods: Thirty adult cases who were followed up in the infection clinic with positive SARS CoV 2 RT-PCR and diagnosed with COVID 19 disease were included in the study with consent. The amino acid profile of these patients' urine samples, 30 different amino acid levels and creatine levels were examined using the liquid chromatography-mass spectrometry (LCMS) method on the SCIEX QTRAP 4500 device. Results: The mean age of the patients is 40 ± 5. Elevated GABA in 28/30 cases, high hydroxylysine amino acid in 27/30 cases, low glycine in 30/30 cases were detected in the urine. The creatinine levels of the patients were found to be normal. Conclusion: It has been thought that the height of GABA may be due to bacteria producing GABA as a result of the change in microbiota due to lactic acidosis, as well as that the virus may directly affect the brain and cause an increase in GABA. https://ijm.tums.ac.ir/index.php/ijm/article/view/5180COVID 19;Urin amino acids;Gamma-aminobutyric acid |
| spellingShingle | Cemal Kazezoglu Arzu İrvem Yasemin Tuba Sutasir Büşra Çakiroglu Banu Kirgiz Habip Yilmaz Ali Kocatas Urine amino acid and gamma aminobutyric acid level in COVID 19 patients Iranian Journal of Microbiology COVID 19; Urin amino acids; Gamma-aminobutyric acid |
| title | Urine amino acid and gamma aminobutyric acid level in COVID 19 patients |
| title_full | Urine amino acid and gamma aminobutyric acid level in COVID 19 patients |
| title_fullStr | Urine amino acid and gamma aminobutyric acid level in COVID 19 patients |
| title_full_unstemmed | Urine amino acid and gamma aminobutyric acid level in COVID 19 patients |
| title_short | Urine amino acid and gamma aminobutyric acid level in COVID 19 patients |
| title_sort | urine amino acid and gamma aminobutyric acid level in covid 19 patients |
| topic | COVID 19; Urin amino acids; Gamma-aminobutyric acid |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/5180 |
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