Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury
Objective: to search for an accessible, valid, and easy-to-use method for the diagnosis and monitoring of a neuronal lesion in severe brain injury (SBI). Subjects and methods. Thirty-three patients aged 18—55 years with isolated SBI (the Glasgow coma scores for admission consciousness were 6±2) were...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2010-02-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/499 |
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| author | M. A. Moldavanov V. Ye. Klimenko A. V. Poleshchuk V. B. Shumatov N. A. Andreyeva D. N. Kirilin |
| author_facet | M. A. Moldavanov V. Ye. Klimenko A. V. Poleshchuk V. B. Shumatov N. A. Andreyeva D. N. Kirilin |
| author_sort | M. A. Moldavanov |
| collection | DOAJ |
| description | Objective: to search for an accessible, valid, and easy-to-use method for the diagnosis and monitoring of a neuronal lesion in severe brain injury (SBI). Subjects and methods. Thirty-three patients aged 18—55 years with isolated SBI (the Glasgow coma scores for admission consciousness were 6±2) were examined; the serum content of neuron-specific protein S-100B was further analyzed. Results and discussion. The cell damage marker concentration was substantially increased in the acute period of brain injury. When the pathological process followed a favorable course, S-100B was considerably decreased just on day 2 of the disease. When the changes were negative, S-100B concentrations remained virtually unchanged or even increased, which was indicative of secondary brain reperfusion/ischemic lesions. The mean baseline marker level varied with the type of brain injury diagnosed by computed tomography; the highest figures being noted in the groups where significant brain tissue lesion was detected. Key words: severe brain injury, prognosis, S-100B protein. |
| format | Article |
| id | doaj-art-ffecbe099b2e4015a6079b96a3f270ac |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2010-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-ffecbe099b2e4015a6079b96a3f270ac2025-08-20T03:59:40ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102010-02-016110.15360/1813-9779-2010-1-17499Diagnosis and Monitoring of Neuronal Lesion in Severe Brain InjuryM. A. MoldavanovV. Ye. KlimenkoA. V. PoleshchukV. B. ShumatovN. A. AndreyevaD. N. KirilinObjective: to search for an accessible, valid, and easy-to-use method for the diagnosis and monitoring of a neuronal lesion in severe brain injury (SBI). Subjects and methods. Thirty-three patients aged 18—55 years with isolated SBI (the Glasgow coma scores for admission consciousness were 6±2) were examined; the serum content of neuron-specific protein S-100B was further analyzed. Results and discussion. The cell damage marker concentration was substantially increased in the acute period of brain injury. When the pathological process followed a favorable course, S-100B was considerably decreased just on day 2 of the disease. When the changes were negative, S-100B concentrations remained virtually unchanged or even increased, which was indicative of secondary brain reperfusion/ischemic lesions. The mean baseline marker level varied with the type of brain injury diagnosed by computed tomography; the highest figures being noted in the groups where significant brain tissue lesion was detected. Key words: severe brain injury, prognosis, S-100B protein.https://www.reanimatology.com/rmt/article/view/499 |
| spellingShingle | M. A. Moldavanov V. Ye. Klimenko A. V. Poleshchuk V. B. Shumatov N. A. Andreyeva D. N. Kirilin Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury Общая реаниматология |
| title | Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury |
| title_full | Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury |
| title_fullStr | Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury |
| title_full_unstemmed | Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury |
| title_short | Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury |
| title_sort | diagnosis and monitoring of neuronal lesion in severe brain injury |
| url | https://www.reanimatology.com/rmt/article/view/499 |
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