Diagnosis and Monitoring of Neuronal Lesion in Severe Brain Injury
Objective: to search for an accessible, valid, and easy-to-use method for the diagnosis and monitoring of a neuronal lesion in severe brain injury (SBI). Subjects and methods. Thirty-three patients aged 18—55 years with isolated SBI (the Glasgow coma scores for admission consciousness were 6±2) were...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2010-02-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/499 |
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| Summary: | Objective: to search for an accessible, valid, and easy-to-use method for the diagnosis and monitoring of a neuronal lesion in severe brain injury (SBI). Subjects and methods. Thirty-three patients aged 18—55 years with isolated SBI (the Glasgow coma scores for admission consciousness were 6±2) were examined; the serum content of neuron-specific protein S-100B was further analyzed. Results and discussion. The cell damage marker concentration was substantially increased in the acute period of brain injury. When the pathological process followed a favorable course, S-100B was considerably decreased just on day 2 of the disease. When the changes were negative, S-100B concentrations remained virtually unchanged or even increased, which was indicative of secondary brain reperfusion/ischemic lesions. The mean baseline marker level varied with the type of brain injury diagnosed by computed tomography; the highest figures being noted in the groups where significant brain tissue lesion was detected. Key words: severe brain injury, prognosis, S-100B protein. |
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| ISSN: | 1813-9779 2411-7110 |