Idiopathic Pulmonary Hypertension and in Situ Thromboembolism: A Difficult Case in Clinical Practice
Pulmonary hypertension is a complex syndrome for differential diagnosis, which is the outcome of various pathological conditions. With the exclusion of the two most common causes of pulmonary hypertension, such as pathology of the left heart chambers and pulmonary embolism, further search for etiolo...
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SINAPS LLC
2024-01-01
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| author | M. A. Us Ju. Ju. Karpenko |
| author_facet | M. A. Us Ju. Ju. Karpenko |
| author_sort | M. A. Us |
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| description | Pulmonary hypertension is a complex syndrome for differential diagnosis, which is the outcome of various pathological conditions. With the exclusion of the two most common causes of pulmonary hypertension, such as pathology of the left heart chambers and pulmonary embolism, further search for etiology often becomes problematic. Despite the emergence of a number of international and domestic recommendations, as well as certain successes in drug therapy, the long-term prognosis in patients with pulmonary arterial hypertension remains unfavorable. In the description of this clinical case in a 39-year-old woman suffering from idiopathic pulmonary arterial hypertension, the main complaint of the patient was very non-specific. The woman could not bear the child, all her attempts, lasting more than 19 years, remained unsuccessful. Even in absolutely healthy women, pregnancy is associated with the highest risks and is a powerful “test” of the body, not to mention patients suffering from rare diseases. The patient has a “subacute” course and a fairly rapid progression of the disease with a significant deterioration in the quality of life, which led to the impossibility of carrying a pregnancy. There were also signs that aggravated the prognosis, such as increased dyspnea, loss of consciousness, a significant decrease in working capacity and a high degree of pulmonary hypertension (according to echocardiography, systolic pressure in the pulmonary artery > 128 mm Hg). Due to the ineffectiveness of standard therapy with a selective inhibitor of cycloguanosine monophosphate — specific phosphodiesterase type 5 — sildenafil; the option of specific therapy for pulmonary hypertension was considered, which made it possible to change the situation and bring the patient into a stable state and draw conclusions about the pregnancy. |
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| institution | Kabale University |
| issn | 2226-6704 2411-6564 |
| language | Russian |
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| spelling | doaj-art-ffe77a4ff456401d864efbae24b89b702025-08-20T03:37:56ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642024-01-0113646647710.20514/2226-6704-2023-13-6-466-477973Idiopathic Pulmonary Hypertension and in Situ Thromboembolism: A Difficult Case in Clinical PracticeM. A. Us0Ju. Ju. Karpenko1State Budgetary Educational Institution of High Professional Education «Voronezh State Medical University n.a. N.N. Burdenko» of the Ministry of Health of the Russian Federation, Department of Hospital Therapy and EndocrinologyState Budgetary Educational Institution of High Professional Education «Voronezh State Medical University n.a. N.N. Burdenko» of the Ministry of Health of the Russian Federation, Department of Hospital Therapy and EndocrinologyPulmonary hypertension is a complex syndrome for differential diagnosis, which is the outcome of various pathological conditions. With the exclusion of the two most common causes of pulmonary hypertension, such as pathology of the left heart chambers and pulmonary embolism, further search for etiology often becomes problematic. Despite the emergence of a number of international and domestic recommendations, as well as certain successes in drug therapy, the long-term prognosis in patients with pulmonary arterial hypertension remains unfavorable. In the description of this clinical case in a 39-year-old woman suffering from idiopathic pulmonary arterial hypertension, the main complaint of the patient was very non-specific. The woman could not bear the child, all her attempts, lasting more than 19 years, remained unsuccessful. Even in absolutely healthy women, pregnancy is associated with the highest risks and is a powerful “test” of the body, not to mention patients suffering from rare diseases. The patient has a “subacute” course and a fairly rapid progression of the disease with a significant deterioration in the quality of life, which led to the impossibility of carrying a pregnancy. There were also signs that aggravated the prognosis, such as increased dyspnea, loss of consciousness, a significant decrease in working capacity and a high degree of pulmonary hypertension (according to echocardiography, systolic pressure in the pulmonary artery > 128 mm Hg). Due to the ineffectiveness of standard therapy with a selective inhibitor of cycloguanosine monophosphate — specific phosphodiesterase type 5 — sildenafil; the option of specific therapy for pulmonary hypertension was considered, which made it possible to change the situation and bring the patient into a stable state and draw conclusions about the pregnancy.https://www.medarhive.ru/jour/article/view/1697idiopathic pulmonary hypertensionin vitro fertilizationpulmonary arteryright ventriclespecific therapy |
| spellingShingle | M. A. Us Ju. Ju. Karpenko Idiopathic Pulmonary Hypertension and in Situ Thromboembolism: A Difficult Case in Clinical Practice Архивъ внутренней медицины idiopathic pulmonary hypertension in vitro fertilization pulmonary artery right ventricle specific therapy |
| title | Idiopathic Pulmonary Hypertension and in Situ Thromboembolism: A Difficult Case in Clinical Practice |
| title_full | Idiopathic Pulmonary Hypertension and in Situ Thromboembolism: A Difficult Case in Clinical Practice |
| title_fullStr | Idiopathic Pulmonary Hypertension and in Situ Thromboembolism: A Difficult Case in Clinical Practice |
| title_full_unstemmed | Idiopathic Pulmonary Hypertension and in Situ Thromboembolism: A Difficult Case in Clinical Practice |
| title_short | Idiopathic Pulmonary Hypertension and in Situ Thromboembolism: A Difficult Case in Clinical Practice |
| title_sort | idiopathic pulmonary hypertension and in situ thromboembolism a difficult case in clinical practice |
| topic | idiopathic pulmonary hypertension in vitro fertilization pulmonary artery right ventricle specific therapy |
| url | https://www.medarhive.ru/jour/article/view/1697 |
| work_keys_str_mv | AT maus idiopathicpulmonaryhypertensionandinsituthromboembolismadifficultcaseinclinicalpractice AT jujukarpenko idiopathicpulmonaryhypertensionandinsituthromboembolismadifficultcaseinclinicalpractice |