GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior
Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HP...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8866187 |
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| author | Yi Zheng Meimei Wu Ting Gao Li Meng Xiaowei Ding Youqiang Meng Yingfu Jiao Ping Luo Zhenquan He Tao Sun Guohua Zhang Xueyin Shi Weifang Rong |
| author_facet | Yi Zheng Meimei Wu Ting Gao Li Meng Xiaowei Ding Youqiang Meng Yingfu Jiao Ping Luo Zhenquan He Tao Sun Guohua Zhang Xueyin Shi Weifang Rong |
| author_sort | Yi Zheng |
| collection | DOAJ |
| description | Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain structures critically involved in mood control. Genetic ablation of GPER in the rat resulted in significantly lower basal serum corticosterone level but enhanced ACTH release in response to acute restraint stress, especially in the female. GPER-/- rats of either sex displayed increased anxiety-like behaviors and deficits in learning and memory. Additionally, GPER deficiency led to aggravation of anxiety-like behaviors following single-prolonged stress (SPS). SPS caused significant decreases in serum corticosterone in WT but not in GPER-deficient rats. The results highlight an important role of GPER at multiple sites in regulation of the HPA axis and mood. |
| format | Article |
| id | doaj-art-ffe752c7e31143f0bce635a9368bb3ca |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ffe752c7e31143f0bce635a9368bb3ca2025-08-20T03:25:54ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88661878866187GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like BehaviorYi Zheng0Meimei Wu1Ting Gao2Li Meng3Xiaowei Ding4Youqiang Meng5Yingfu Jiao6Ping Luo7Zhenquan He8Tao Sun9Guohua Zhang10Xueyin Shi11Weifang Rong12Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anatomy and Physiology, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anatomy and Physiology, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anatomy and Physiology, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anatomy and Physiology, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anatomy and Physiology, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaKey Laboratory of Cerebrocranial Diseases, Ningxia Medical University, Yinchuan 750004, ChinaKey Laboratory of Cerebrocranial Diseases, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Anatomy and Physiology, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaAmple evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood. Through multiple approaches, we demonstrate that the G protein-coupled estrogen receptor (GPER) is widely distributed along the HPA axis and in brain structures critically involved in mood control. Genetic ablation of GPER in the rat resulted in significantly lower basal serum corticosterone level but enhanced ACTH release in response to acute restraint stress, especially in the female. GPER-/- rats of either sex displayed increased anxiety-like behaviors and deficits in learning and memory. Additionally, GPER deficiency led to aggravation of anxiety-like behaviors following single-prolonged stress (SPS). SPS caused significant decreases in serum corticosterone in WT but not in GPER-deficient rats. The results highlight an important role of GPER at multiple sites in regulation of the HPA axis and mood.http://dx.doi.org/10.1155/2020/8866187 |
| spellingShingle | Yi Zheng Meimei Wu Ting Gao Li Meng Xiaowei Ding Youqiang Meng Yingfu Jiao Ping Luo Zhenquan He Tao Sun Guohua Zhang Xueyin Shi Weifang Rong GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior Neural Plasticity |
| title | GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior |
| title_full | GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior |
| title_fullStr | GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior |
| title_full_unstemmed | GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior |
| title_short | GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior |
| title_sort | gper deficient rats exhibit lower serum corticosterone level and increased anxiety like behavior |
| url | http://dx.doi.org/10.1155/2020/8866187 |
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