Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients
Objective. To investigate changes in the glycated hemoglobin A1c (A1c) level and those in β cell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients and to evaluate the relationship between them. Design and Methods. A total of 818 newly diagnosed diabetic indi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/8797316 |
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| author | Xinguo Hou Jinbo Liu Jun Song Chuan Wang Kai Liang Yu Sun Zeqiang Ma Weifang Yang Chengqiao Li Xiuping Zhang Peng Lin Lei Gong Meijian Wang Fuqiang Liu Wenjuan Li Fei Yan Jun Qin Lingshu Wang Jidong Liu Ruxing Zhao Shihong Chen Li Chen |
| author_facet | Xinguo Hou Jinbo Liu Jun Song Chuan Wang Kai Liang Yu Sun Zeqiang Ma Weifang Yang Chengqiao Li Xiuping Zhang Peng Lin Lei Gong Meijian Wang Fuqiang Liu Wenjuan Li Fei Yan Jun Qin Lingshu Wang Jidong Liu Ruxing Zhao Shihong Chen Li Chen |
| author_sort | Xinguo Hou |
| collection | DOAJ |
| description | Objective. To investigate changes in the glycated hemoglobin A1c (A1c) level and those in β cell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients and to evaluate the relationship between them. Design and Methods. A total of 818 newly diagnosed diabetic individuals who were ≥40 years of age were recruited. The subjects were grouped by A1c values (<6.5%, 6.5–7%, 7-8%, 8-9%, and ≥9%). The homeostasis model assessment (HOMA) was used to evaluate pancreatic β cell function (HOMA-β) and insulin resistance (HOMA-IR). ANOVA, t-tests, and binary logistic regression analysis were used for data analysis. Results. Compared with subjects with A1c values <6.5%, individuals with an A1c of 6.5–7% exhibited an increased HOMA-β index. However, the HOMA-β index was significantly decreased at A1c values ≥7% and further decreased by 9.3% and by 23.7%, respectively, at A1c values of 7-8% and 8-9%. As A1c increased to ≥9%, a 62% reduction in β cell function was observed, independently of age, gender, body mass index (BMI), blood pressure (BP), blood lipids, and hepatic enzyme levels. Meanwhile, insulin resistance was significantly increased with an increase in A1c values. Conclusions. Elevated A1c values (≥7%) were associated with substantial reductions in β cell function. |
| format | Article |
| id | doaj-art-ffe40797f2da495cb2665b2e9d7e0fc4 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ffe40797f2da495cb2665b2e9d7e0fc42025-08-20T02:22:50ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/87973168797316Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes PatientsXinguo Hou0Jinbo Liu1Jun Song2Chuan Wang3Kai Liang4Yu Sun5Zeqiang Ma6Weifang Yang7Chengqiao Li8Xiuping Zhang9Peng Lin10Lei Gong11Meijian Wang12Fuqiang Liu13Wenjuan Li14Fei Yan15Jun Qin16Lingshu Wang17Jidong Liu18Ruxing Zhao19Shihong Chen20Li Chen21Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaChina National Heavy Duty Truck Group Corporation Hospital, Jinan, Shandong 250116, ChinaLukang Hospital of Jining, Jining, Shandong 272141, ChinaDepartment of Endocrinology, Second People’s Hospital of Jining, Jining, Shandong 272049, ChinaShantui Community Health Center, Jining, Shandong 272000, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, The Second Hospital of Shandong University, Jinan, Shandong 250012, ChinaDepartment of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, ChinaObjective. To investigate changes in the glycated hemoglobin A1c (A1c) level and those in β cell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients and to evaluate the relationship between them. Design and Methods. A total of 818 newly diagnosed diabetic individuals who were ≥40 years of age were recruited. The subjects were grouped by A1c values (<6.5%, 6.5–7%, 7-8%, 8-9%, and ≥9%). The homeostasis model assessment (HOMA) was used to evaluate pancreatic β cell function (HOMA-β) and insulin resistance (HOMA-IR). ANOVA, t-tests, and binary logistic regression analysis were used for data analysis. Results. Compared with subjects with A1c values <6.5%, individuals with an A1c of 6.5–7% exhibited an increased HOMA-β index. However, the HOMA-β index was significantly decreased at A1c values ≥7% and further decreased by 9.3% and by 23.7%, respectively, at A1c values of 7-8% and 8-9%. As A1c increased to ≥9%, a 62% reduction in β cell function was observed, independently of age, gender, body mass index (BMI), blood pressure (BP), blood lipids, and hepatic enzyme levels. Meanwhile, insulin resistance was significantly increased with an increase in A1c values. Conclusions. Elevated A1c values (≥7%) were associated with substantial reductions in β cell function.http://dx.doi.org/10.1155/2016/8797316 |
| spellingShingle | Xinguo Hou Jinbo Liu Jun Song Chuan Wang Kai Liang Yu Sun Zeqiang Ma Weifang Yang Chengqiao Li Xiuping Zhang Peng Lin Lei Gong Meijian Wang Fuqiang Liu Wenjuan Li Fei Yan Jun Qin Lingshu Wang Jidong Liu Ruxing Zhao Shihong Chen Li Chen Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients Journal of Diabetes Research |
| title | Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients |
| title_full | Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients |
| title_fullStr | Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients |
| title_full_unstemmed | Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients |
| title_short | Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients |
| title_sort | relationship of hemoglobin a1c with β cell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients |
| url | http://dx.doi.org/10.1155/2016/8797316 |
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