Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney disease
Aim. To investigate the renal transplantation results for patients with end-stage renal disease (ESRD) due to autosomal dominant polycystic kidney disease (PKD).Materials and methods. The study included a prospective and retrospective analysis of the kidney transplantation results in 46 patients wit...
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2019-07-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1019 |
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| author | V. S. Daineko A. N. Ananiev E. S. Nevirovich A. E. Skvorcov S. A. Budylev А. N. Selivanov M. M. Moskalenko V. A. Manukovskiy O. N. Reznik |
| author_facet | V. S. Daineko A. N. Ananiev E. S. Nevirovich A. E. Skvorcov S. A. Budylev А. N. Selivanov M. M. Moskalenko V. A. Manukovskiy O. N. Reznik |
| author_sort | V. S. Daineko |
| collection | DOAJ |
| description | Aim. To investigate the renal transplantation results for patients with end-stage renal disease (ESRD) due to autosomal dominant polycystic kidney disease (PKD).Materials and methods. The study included a prospective and retrospective analysis of the kidney transplantation results in 46 patients with ESRD caused by PKD, performed in the period from 2003 to 2018. Two groups of patients were formed. The comparison group consisted of 23 (50%) cases of kidney transplantation in patients whose polycystic-changed kidneys were preserved at the time of transplantation. The study group included 23 (50%) patients who underwent pretransplantation nephrectomy of native kidneys for clinical indications or to prepare for the waiting list. During the study, an algorithm of examination and surgical preparation for inclusion patients with PKD in the waiting list for kidney transplantation was developed and actively used.Results. The mean follow up period of patients who underwent pretransplantation nephrectomy was 3.6 ± 2.5 years, patients with preserved native kidneys - 5.3 ± 3.08 years (p > 0.05). Periodic pain in the lumbar region disturbed 12 (52.2%) patients with preserved polycystic-changed kidneys. The frequency of episodes of leukocyturia, bacteriuria and(or) hematuria significantly differed and amounted to 0.27 ± 0.35 cases per year in the study group, 1.49 ± 0.54 (p < 0.05) in the comparison group. Posttransplant nephrectomy of polycystic-changed kidneys at different times after transplantation was required in 5 (21.7%) patients. Five-year graft survival in the study group was 87.5%, in the comparison group - 76.1%. Among the patients of the comparison group, 76.4% of transplants lost their function after 10 years. The 5 and 10-year survival rates of patients with preserved native kidneys were 90.5% and 80%, respectively. In particular, there was one fatal outcome due to sepsis on the background of infection with cysts of preserved polycystic kidney. There were no deaths in the study group.Conclusion. Among patients whom polycystic-changed kidneys removed, there is a more favorable course of the post-transplant period due to the low frequency of infectious complications. More than 60% of patients with PKD need to perform nephrectomy of native kidneys during life for various reasons, including more than 21,7% need it after kidney transplantation due to complications during immunosuppressive therapy. Reasonable assessment of the polycystic kidneys and timely pretransplantation nephrectomy are an integral part of the preparation and management of the waiting list for transplantation of a patient with PKD. |
| format | Article |
| id | doaj-art-ffe397cabfa5457ebb599d20c72ec879 |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-ffe397cabfa5457ebb599d20c72ec8792025-08-20T03:01:38ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912019-07-01212394810.15825/1995-1191-2019-2-39-48782Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney diseaseV. S. Daineko0A. N. Ananiev1E. S. Nevirovich2A. E. Skvorcov3S. A. Budylev4А. N. Selivanov5M. M. Moskalenko6V. A. Manukovskiy7O. N. Reznik8I.I. Dzhanelidze Saint Petersburg Research Institute of Emergency MedicineI.P. Pavlov First Saint Petersburg State Medical UniversityI.P. Pavlov First Saint Petersburg State Medical UniversityI.P. Pavlov First Saint Petersburg State Medical UniversityClinical hospital № 31Clinical hospital № 31Clinical hospital № 31I.I. Dzhanelidze Saint Petersburg Research Institute of Emergency MedicineI.I. Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine; I.P. Pavlov First Saint Petersburg State Medical University; I.I. Mechnikov North-Western State Medical UniversityAim. To investigate the renal transplantation results for patients with end-stage renal disease (ESRD) due to autosomal dominant polycystic kidney disease (PKD).Materials and methods. The study included a prospective and retrospective analysis of the kidney transplantation results in 46 patients with ESRD caused by PKD, performed in the period from 2003 to 2018. Two groups of patients were formed. The comparison group consisted of 23 (50%) cases of kidney transplantation in patients whose polycystic-changed kidneys were preserved at the time of transplantation. The study group included 23 (50%) patients who underwent pretransplantation nephrectomy of native kidneys for clinical indications or to prepare for the waiting list. During the study, an algorithm of examination and surgical preparation for inclusion patients with PKD in the waiting list for kidney transplantation was developed and actively used.Results. The mean follow up period of patients who underwent pretransplantation nephrectomy was 3.6 ± 2.5 years, patients with preserved native kidneys - 5.3 ± 3.08 years (p > 0.05). Periodic pain in the lumbar region disturbed 12 (52.2%) patients with preserved polycystic-changed kidneys. The frequency of episodes of leukocyturia, bacteriuria and(or) hematuria significantly differed and amounted to 0.27 ± 0.35 cases per year in the study group, 1.49 ± 0.54 (p < 0.05) in the comparison group. Posttransplant nephrectomy of polycystic-changed kidneys at different times after transplantation was required in 5 (21.7%) patients. Five-year graft survival in the study group was 87.5%, in the comparison group - 76.1%. Among the patients of the comparison group, 76.4% of transplants lost their function after 10 years. The 5 and 10-year survival rates of patients with preserved native kidneys were 90.5% and 80%, respectively. In particular, there was one fatal outcome due to sepsis on the background of infection with cysts of preserved polycystic kidney. There were no deaths in the study group.Conclusion. Among patients whom polycystic-changed kidneys removed, there is a more favorable course of the post-transplant period due to the low frequency of infectious complications. More than 60% of patients with PKD need to perform nephrectomy of native kidneys during life for various reasons, including more than 21,7% need it after kidney transplantation due to complications during immunosuppressive therapy. Reasonable assessment of the polycystic kidneys and timely pretransplantation nephrectomy are an integral part of the preparation and management of the waiting list for transplantation of a patient with PKD.https://journal.transpl.ru/vtio/article/view/1019autosomal dominant polycystic kidney diseasekidney transplantation |
| spellingShingle | V. S. Daineko A. N. Ananiev E. S. Nevirovich A. E. Skvorcov S. A. Budylev А. N. Selivanov M. M. Moskalenko V. A. Manukovskiy O. N. Reznik Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney disease Вестник трансплантологии и искусственных органов autosomal dominant polycystic kidney disease kidney transplantation |
| title | Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney disease |
| title_full | Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney disease |
| title_fullStr | Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney disease |
| title_full_unstemmed | Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney disease |
| title_short | Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney disease |
| title_sort | results of kidney transplantation in patients with end stage renal failure caused by autosomal dominant polycystic kidney disease |
| topic | autosomal dominant polycystic kidney disease kidney transplantation |
| url | https://journal.transpl.ru/vtio/article/view/1019 |
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