The effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilization
Abstract Whether surgical treatment of tubal pregnancy affects the outcomes of concomitant live normally sited (eutopic) pregnancies is unknown. The purpose of this study was to investigate the outcomes of live eutopic singleton pregnancies following surgical treatment for concomitant fallopian preg...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-88519-x |
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| author | Pei Cai Mingxiang Zheng Yangqin Peng Yuyao Mao Fei Gong Hui Chen Ge Lin Yan Ouyang Xihong Li |
| author_facet | Pei Cai Mingxiang Zheng Yangqin Peng Yuyao Mao Fei Gong Hui Chen Ge Lin Yan Ouyang Xihong Li |
| author_sort | Pei Cai |
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| description | Abstract Whether surgical treatment of tubal pregnancy affects the outcomes of concomitant live normally sited (eutopic) pregnancies is unknown. The purpose of this study was to investigate the outcomes of live eutopic singleton pregnancies following surgical treatment for concomitant fallopian pregnancies. A total of 446 patients who conceived tubal heterotopic pregnancies (HPs) via in vitro fertilization–embryo transfer and underwent surgical treatment to remove ectopic pregnancies (EPs) were included. For each study patient, one matched patient who conceived a live eutopic singleton pregnancy was selected randomly as a control. The rates of early miscarriage, late miscarriage, live birth, preterm birth, low birth weight and perinatal mortality were not significantly different between the study and control groups. The birth weight were also similar between these two groups. However, the caesarean section rate was significantly higher in the study group than that in the control group(P < 0.001). Additionally, laparotomy and laparoscopy for tubal HPs yielded similar pregnancy outcomes. Compared with controls, patients who conceived tubal pregnancies and concomitant live eutopic singleton pregnancies had similar pregnancy outcomes after proper surgical treatment of EPs. These findings can be used for counselling women who have conceived tubal HPs regarding the risks associated with surgical treatment. |
| format | Article |
| id | doaj-art-ffe24c500c0647b7952b56685d2b76b3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ffe24c500c0647b7952b56685d2b76b32025-02-09T12:34:33ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-88519-xThe effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilizationPei Cai0Mingxiang Zheng1Yangqin Peng2Yuyao Mao3Fei Gong4Hui Chen5Ge Lin6Yan Ouyang7Xihong Li8Reproductive and Genetic Hospital of CITIC-XiangyaReproductive and Genetic Hospital of CITIC-XiangyaReproductive and Genetic Hospital of CITIC-XiangyaReproductive and Genetic Hospital of CITIC-XiangyaReproductive and Genetic Hospital of CITIC-XiangyaReproductive and Genetic Hospital of CITIC-XiangyaReproductive and Genetic Hospital of CITIC-XiangyaReproductive and Genetic Hospital of CITIC-XiangyaReproductive and Genetic Hospital of CITIC-XiangyaAbstract Whether surgical treatment of tubal pregnancy affects the outcomes of concomitant live normally sited (eutopic) pregnancies is unknown. The purpose of this study was to investigate the outcomes of live eutopic singleton pregnancies following surgical treatment for concomitant fallopian pregnancies. A total of 446 patients who conceived tubal heterotopic pregnancies (HPs) via in vitro fertilization–embryo transfer and underwent surgical treatment to remove ectopic pregnancies (EPs) were included. For each study patient, one matched patient who conceived a live eutopic singleton pregnancy was selected randomly as a control. The rates of early miscarriage, late miscarriage, live birth, preterm birth, low birth weight and perinatal mortality were not significantly different between the study and control groups. The birth weight were also similar between these two groups. However, the caesarean section rate was significantly higher in the study group than that in the control group(P < 0.001). Additionally, laparotomy and laparoscopy for tubal HPs yielded similar pregnancy outcomes. Compared with controls, patients who conceived tubal pregnancies and concomitant live eutopic singleton pregnancies had similar pregnancy outcomes after proper surgical treatment of EPs. These findings can be used for counselling women who have conceived tubal HPs regarding the risks associated with surgical treatment.https://doi.org/10.1038/s41598-025-88519-xEctopicHeterotopic pregnancyLaparoscopyLaparotomyMiscarriage rateIn vitro fertilization–embryo transfer |
| spellingShingle | Pei Cai Mingxiang Zheng Yangqin Peng Yuyao Mao Fei Gong Hui Chen Ge Lin Yan Ouyang Xihong Li The effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilization Scientific Reports Ectopic Heterotopic pregnancy Laparoscopy Laparotomy Miscarriage rate In vitro fertilization–embryo transfer |
| title | The effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilization |
| title_full | The effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilization |
| title_fullStr | The effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilization |
| title_full_unstemmed | The effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilization |
| title_short | The effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilization |
| title_sort | effect of surgical treatment of tubal pregnancy on concurrent intrauterine pregnancy after in vitro fertilization |
| topic | Ectopic Heterotopic pregnancy Laparoscopy Laparotomy Miscarriage rate In vitro fertilization–embryo transfer |
| url | https://doi.org/10.1038/s41598-025-88519-x |
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