A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR

A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR

Abstract Bitter taste receptors (TAS2Rs), a subfamily of G-protein coupled receptors (GPCRs) expressed orally and extraorally, elicit signaling in response to a large set of tastants. Among 25 functional TAS2Rs encoded in the human genome, TAS2R14 is the most promiscuous, and responds to hundreds of...

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Main Authors: Lior Peri, Donna Matzov, Dominic R. Huxley, Alon Rainish, Fabrizio Fierro, Liel Sapir, Tara Pfeiffer, Lukas Waterloo, Harald Hübner, Yoav Peleg, Peter Gmeiner, Peter J. McCormick, Dorothee Weikert, Masha Y. Niv, Moran Shalev-Benami
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54157-6
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