Research Progress on Th17/Treg Cell Imbalance in Epileptic Seizures
Liu Mu,1,2 Yan Rong,1– 3,* Yang Jia Xin,1,2,* Hong Zhang,1,2,* Zucai Xu1– 3 1Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, People’s Republic of China; 2Key Laboratory of Brain Function and Brain Disease Preventio...
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Dove Medical Press
2025-06-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/research-progress-on-th17treg-cell-imbalance-in-epileptic-seizures-peer-reviewed-fulltext-article-JIR |
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| author | Mu L Rong Y Xin YJ Zhang H Xu Z |
| author_facet | Mu L Rong Y Xin YJ Zhang H Xu Z |
| author_sort | Mu L |
| collection | DOAJ |
| description | Liu Mu,1,2 Yan Rong,1– 3,* Yang Jia Xin,1,2,* Hong Zhang,1,2,* Zucai Xu1– 3 1Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, People’s Republic of China; 2Key Laboratory of Brain Function and Brain Disease Prevention and Treatment of Guizhou Province, Zunyi, Guizhou, 563003, People’s Republic of China; 3Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi, Guizhou, 563003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zucai Xu, Department of Neurology, The Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, Guizhou, 563003, People’s Republic of China, Email docxzc@126.comAbstract: Epilepsy is associated with widespread neurological circumstances due to aberrant neuronal discharges in the brain, which have significant adverse effects on patient’s quality of life and increase their risk of death. Immune imbalance, particularly disruption of the Th17/Treg cell balance, has gained increasing attention in the pathophysiology of epilepsy as our understanding of neuroimmune interactions improves. This paper examines the potential therapeutic effects and thoroughly discusses the processes by which the Th17/Treg cell imbalance contributes to the development of epilepsy. The primary emphasis is on the mechanism by which this imbalance impairs blood–brain barrier integrity, neuroinflammation, and other elements. On the therapeutic front, targeting the Th17/Treg axis for immune regulation—through approaches such as ketogenic diets, nanomaterials, and gene editing—shows promising prospects for restoring immune balance. By furthering our knowledge of the connection between Th17/Treg cell imbalance and epilepsy etiology, this work offers a crucial theoretical foundation for creating innovative immunotherapy approaches.Keywords: epilepsy, Th17/Treg cell balance, neuroinflammation, immune regulation, neuroimmune regulation |
| format | Article |
| id | doaj-art-ffde196d77da4004a3208ee6cd5aef7c |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-ffde196d77da4004a3208ee6cd5aef7c2025-08-20T03:29:49ZengDove Medical PressJournal of Inflammation Research1178-70312025-06-01Volume 18Issue 177697779103870Research Progress on Th17/Treg Cell Imbalance in Epileptic SeizuresMu L0Rong Y1Xin YJ2Zhang H3Xu Z4Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyLiu Mu,1,2 Yan Rong,1– 3,* Yang Jia Xin,1,2,* Hong Zhang,1,2,* Zucai Xu1– 3 1Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, People’s Republic of China; 2Key Laboratory of Brain Function and Brain Disease Prevention and Treatment of Guizhou Province, Zunyi, Guizhou, 563003, People’s Republic of China; 3Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi, Guizhou, 563003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zucai Xu, Department of Neurology, The Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, Guizhou, 563003, People’s Republic of China, Email docxzc@126.comAbstract: Epilepsy is associated with widespread neurological circumstances due to aberrant neuronal discharges in the brain, which have significant adverse effects on patient’s quality of life and increase their risk of death. Immune imbalance, particularly disruption of the Th17/Treg cell balance, has gained increasing attention in the pathophysiology of epilepsy as our understanding of neuroimmune interactions improves. This paper examines the potential therapeutic effects and thoroughly discusses the processes by which the Th17/Treg cell imbalance contributes to the development of epilepsy. The primary emphasis is on the mechanism by which this imbalance impairs blood–brain barrier integrity, neuroinflammation, and other elements. On the therapeutic front, targeting the Th17/Treg axis for immune regulation—through approaches such as ketogenic diets, nanomaterials, and gene editing—shows promising prospects for restoring immune balance. By furthering our knowledge of the connection between Th17/Treg cell imbalance and epilepsy etiology, this work offers a crucial theoretical foundation for creating innovative immunotherapy approaches.Keywords: epilepsy, Th17/Treg cell balance, neuroinflammation, immune regulation, neuroimmune regulationhttps://www.dovepress.com/research-progress-on-th17treg-cell-imbalance-in-epileptic-seizures-peer-reviewed-fulltext-article-JIREpilepsyTh17/Treg Cell BalanceNeuroinflammationImmune RegulationNeuroimmune Regulation |
| spellingShingle | Mu L Rong Y Xin YJ Zhang H Xu Z Research Progress on Th17/Treg Cell Imbalance in Epileptic Seizures Journal of Inflammation Research Epilepsy Th17/Treg Cell Balance Neuroinflammation Immune Regulation Neuroimmune Regulation |
| title | Research Progress on Th17/Treg Cell Imbalance in Epileptic Seizures |
| title_full | Research Progress on Th17/Treg Cell Imbalance in Epileptic Seizures |
| title_fullStr | Research Progress on Th17/Treg Cell Imbalance in Epileptic Seizures |
| title_full_unstemmed | Research Progress on Th17/Treg Cell Imbalance in Epileptic Seizures |
| title_short | Research Progress on Th17/Treg Cell Imbalance in Epileptic Seizures |
| title_sort | research progress on th17 treg cell imbalance in epileptic seizures |
| topic | Epilepsy Th17/Treg Cell Balance Neuroinflammation Immune Regulation Neuroimmune Regulation |
| url | https://www.dovepress.com/research-progress-on-th17treg-cell-imbalance-in-epileptic-seizures-peer-reviewed-fulltext-article-JIR |
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