MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation
Abstract The cerebral venous system plays a crucial role in neurological and vascular conditions, yet its hemodynamics remain underexplored due to its complexity and variability across individuals. To address this, we develop a venous perfusion source mapping method using Displacement Spectrum MRI,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-59108-3 |
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| author | Ekin Karasan Jingjia Chen Julian Maravilla Zhiyong Zhang Chunlei Liu Michael Lustig |
| author_facet | Ekin Karasan Jingjia Chen Julian Maravilla Zhiyong Zhang Chunlei Liu Michael Lustig |
| author_sort | Ekin Karasan |
| collection | DOAJ |
| description | Abstract The cerebral venous system plays a crucial role in neurological and vascular conditions, yet its hemodynamics remain underexplored due to its complexity and variability across individuals. To address this, we develop a venous perfusion source mapping method using Displacement Spectrum MRI, a non-contrast technique that leverages blood water as an endogenous tracer. Our technique encodes spatial information into the magnetization of blood water spins during tagging and detects it once the tagged blood reaches the brain’s surface, where the signal-to-noise ratio is 3–4 times higher. We resolve the sources of blood entering the imaging slice across short (10 ms) to long (3 s) evolution times, effectively capturing perfusion sources in reverse. This approach enables the measurement of slow venous blood flow, including potential contributions from capillary beds and surrounding tissue. We demonstrate perfusion source mapping in the superior cerebral veins, verify its sensitivity to global perfusion modulation induced by caffeine, and establish its specificity by showing repeatable local perfusion modulation during neural activation. From all blood within the imaging slice, our method localizes the portion originating from an activated region upstream. |
| format | Article |
| id | doaj-art-ffd4ce1c8d6f48419fa5ea1c47068267 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-ffd4ce1c8d6f48419fa5ea1c470682672025-08-20T03:15:09ZengNature PortfolioNature Communications2041-17232025-04-0116111510.1038/s41467-025-59108-3MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activationEkin Karasan0Jingjia Chen1Julian Maravilla2Zhiyong Zhang3Chunlei Liu4Michael Lustig5Department of Electrical Engineering and Computer Sciences, University of California, BerkeleyDepartment of Electrical Engineering and Computer Sciences, University of California, BerkeleyDepartment of Electrical Engineering and Computer Sciences, University of California, BerkeleySchool of Biomedical Engineering, Shanghai Jiao Tong UniversityDepartment of Electrical Engineering and Computer Sciences, University of California, BerkeleyDepartment of Electrical Engineering and Computer Sciences, University of California, BerkeleyAbstract The cerebral venous system plays a crucial role in neurological and vascular conditions, yet its hemodynamics remain underexplored due to its complexity and variability across individuals. To address this, we develop a venous perfusion source mapping method using Displacement Spectrum MRI, a non-contrast technique that leverages blood water as an endogenous tracer. Our technique encodes spatial information into the magnetization of blood water spins during tagging and detects it once the tagged blood reaches the brain’s surface, where the signal-to-noise ratio is 3–4 times higher. We resolve the sources of blood entering the imaging slice across short (10 ms) to long (3 s) evolution times, effectively capturing perfusion sources in reverse. This approach enables the measurement of slow venous blood flow, including potential contributions from capillary beds and surrounding tissue. We demonstrate perfusion source mapping in the superior cerebral veins, verify its sensitivity to global perfusion modulation induced by caffeine, and establish its specificity by showing repeatable local perfusion modulation during neural activation. From all blood within the imaging slice, our method localizes the portion originating from an activated region upstream.https://doi.org/10.1038/s41467-025-59108-3 |
| spellingShingle | Ekin Karasan Jingjia Chen Julian Maravilla Zhiyong Zhang Chunlei Liu Michael Lustig MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation Nature Communications |
| title | MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation |
| title_full | MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation |
| title_fullStr | MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation |
| title_full_unstemmed | MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation |
| title_short | MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation |
| title_sort | mr perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation |
| url | https://doi.org/10.1038/s41467-025-59108-3 |
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