Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development
Introduction. Interstitial Cells of Cajal (ICCs) play a critical role in the regulation of gastrointestinal motility and have been implicated in various functional gastrointestinal disorders. Recent research indicates a possible association between ICCs and the tumor risk of Gastrointestinal Stromal...
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MDPI AG
2024-10-01
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| Series: | Journal of Mind and Medical Sciences |
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| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1537&context=jmms |
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| author | Petru Radu Mihai Zurzu Anca Tigora Vlad Paic Mircea Bratucu Dragos Garofil Valeriu Surlin Stefan Patrascu Virgiliu Prunoiu Ionut Simion Coman Valentin Georgescu Razvan Daniel Chivu Florian Popa Victor Strambu Raluca Gabriela Ioan |
| author_facet | Petru Radu Mihai Zurzu Anca Tigora Vlad Paic Mircea Bratucu Dragos Garofil Valeriu Surlin Stefan Patrascu Virgiliu Prunoiu Ionut Simion Coman Valentin Georgescu Razvan Daniel Chivu Florian Popa Victor Strambu Raluca Gabriela Ioan |
| author_sort | Petru Radu |
| collection | DOAJ |
| description | Introduction. Interstitial Cells of Cajal (ICCs) play a critical role in the regulation of gastrointestinal motility and have been implicated in various functional gastrointestinal disorders. Recent research indicates a possible association between ICCs and the tumor risk of Gastrointestinal Stromal Tumors (GISTs). This research aims to examine the clinical, histopathological, and biomolecular characteristics of ICCs and their relevance in assessing GIST risk. Materials and Methods. This study examined fourteen GIST patients who underwent surgical intervention at the Surgery Department of Carol Davila Nephrology Hospital in Bucharest. Parameters including age, gender, tumor location/ dimensions were scrutinized. Immunohistochemistry employing markers CD117, DOG-1, and CD34 was employed to ascertain the presence of ICCs and GISTs. Results. The GIST risk stratification revealed distribution with 35.71% very low-risk, 21.42% low-risk, 14.28% intermediate-risk, and 28.57% high-risk categories. Predominantly, 57.14% of cases fell within the very low-risk and low-risk categories. Positive immunoreactivity for CD117 and DOG-1 was noted in 92.86% of patients, while CD34 exhibited positivity in 85.71% of cases. Gastric GISTs manifested heightened marker expression. Notably, immunohistochemistry unveiled robust positivity for CD117, DOG-1, and CD34, illustrating a positive correlation between elevated ICC levels and high-risk GISTs. Conclusions. The findings propose an association between ICC levels and high-risk GISTs, accentuating the diagnostic utility of CD117, DOG-1, and CD34 markers in GIST assessment. |
| format | Article |
| id | doaj-art-ffd283f497a44d0ea341fba0dcf663cd |
| institution | DOAJ |
| issn | 2392-7674 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-ffd283f497a44d0ea341fba0dcf663cd2025-08-20T03:06:13ZengMDPI AGJournal of Mind and Medical Sciences2392-76742024-10-0111241241910.22543/2392-7674.1537Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease developmentPetru Radu0Mihai Zurzu1Anca Tigora2Vlad Paic3Mircea Bratucu4Dragos Garofil5Valeriu Surlin6Stefan Patrascu7Virgiliu Prunoiu8Ionut Simion Coman9Valentin Georgescu10Razvan Daniel Chivu11Florian Popa12Victor Strambu13Raluca Gabriela Ioan14Carol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCraiova University of Medicine and Pharmacy, sixth Department of Surgery, Craiova, RomaniaCraiova University of Medicine and Pharmacy, sixth Department of Surgery, Craiova, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Department of Social Medicine, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, tenth Department of Surgery, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Faculty of Midwifery and Nursing, Department of Gynecology, Bucharest, RomaniaIntroduction. Interstitial Cells of Cajal (ICCs) play a critical role in the regulation of gastrointestinal motility and have been implicated in various functional gastrointestinal disorders. Recent research indicates a possible association between ICCs and the tumor risk of Gastrointestinal Stromal Tumors (GISTs). This research aims to examine the clinical, histopathological, and biomolecular characteristics of ICCs and their relevance in assessing GIST risk. Materials and Methods. This study examined fourteen GIST patients who underwent surgical intervention at the Surgery Department of Carol Davila Nephrology Hospital in Bucharest. Parameters including age, gender, tumor location/ dimensions were scrutinized. Immunohistochemistry employing markers CD117, DOG-1, and CD34 was employed to ascertain the presence of ICCs and GISTs. Results. The GIST risk stratification revealed distribution with 35.71% very low-risk, 21.42% low-risk, 14.28% intermediate-risk, and 28.57% high-risk categories. Predominantly, 57.14% of cases fell within the very low-risk and low-risk categories. Positive immunoreactivity for CD117 and DOG-1 was noted in 92.86% of patients, while CD34 exhibited positivity in 85.71% of cases. Gastric GISTs manifested heightened marker expression. Notably, immunohistochemistry unveiled robust positivity for CD117, DOG-1, and CD34, illustrating a positive correlation between elevated ICC levels and high-risk GISTs. Conclusions. The findings propose an association between ICC levels and high-risk GISTs, accentuating the diagnostic utility of CD117, DOG-1, and CD34 markers in GIST assessment.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1537&context=jmmsgistcajal cellscd117cd34dog-1iccimmunohistochemistry |
| spellingShingle | Petru Radu Mihai Zurzu Anca Tigora Vlad Paic Mircea Bratucu Dragos Garofil Valeriu Surlin Stefan Patrascu Virgiliu Prunoiu Ionut Simion Coman Valentin Georgescu Razvan Daniel Chivu Florian Popa Victor Strambu Raluca Gabriela Ioan Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development Journal of Mind and Medical Sciences gist cajal cells cd117 cd34 dog-1 icc immunohistochemistry |
| title | Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development |
| title_full | Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development |
| title_fullStr | Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development |
| title_full_unstemmed | Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development |
| title_short | Gastrointestinal stromal tumors: a focus on the impact of interstitial cells of Cajal in disease development |
| title_sort | gastrointestinal stromal tumors a focus on the impact of interstitial cells of cajal in disease development |
| topic | gist cajal cells cd117 cd34 dog-1 icc immunohistochemistry |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1537&context=jmms |
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