Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen
The aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colon specific drug delivery of naproxen. The core tablets were prepared by wet granulation method then press coated with hyd...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/654829 |
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| _version_ | 1850161373887070208 |
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| author | Pooja Sharma Anuj Chawla Pravin Pawar |
| author_facet | Pooja Sharma Anuj Chawla Pravin Pawar |
| author_sort | Pooja Sharma |
| collection | DOAJ |
| description | The aim of present investigation deals with the development of time-dependent
and pH sensitive press-coated tablets for colon specific drug delivery of naproxen.
The core tablets were prepared by wet granulation method then press coated with
hydroxypropyl cellulose (HPC) or Eudragit RSPO : RLPO mixture
and further coated with Eudragit S-100 by dip immerse method. The in vitro drug
release study was conducted in different dissolution media such as pH 1.2, 6.8, and 7.4
with or without rat caecal content to simulate GIT conditions. Surface morphology and
cross-sectional view of the tablets were visualized by scanning electron microscopy
(SEM). All prepared batches were in compliance with the pharmacopoeial standards.
The tablets which are compression coated with HPC followed by Eudragit S-100 coated
showed highest in vitro drug release of 98.10% in presence of rat
caecal content. The SEM of tablets suggested that the number of pores got increased
in pH 7.4 medium followed by dissolution of coating layer. The tablets coat erosion study
suggested that the lag time depends upon the coating concentrations of polymers.
A time-dependent hydrophilic polymer and pH sensitive polymer based press-coated
tablets of naproxen were promising delivery for colon targeting. |
| format | Article |
| id | doaj-art-ffca5aac5f19463b8ccbd9a5a3a464c8 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ffca5aac5f19463b8ccbd9a5a3a464c82025-08-20T02:22:50ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/654829654829Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of NaproxenPooja Sharma0Anuj Chawla1Pravin Pawar2Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway, Rajpura, Patiala, Punjab 140401, IndiaChitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway, Rajpura, Patiala, Punjab 140401, IndiaChitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway, Rajpura, Patiala, Punjab 140401, IndiaThe aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colon specific drug delivery of naproxen. The core tablets were prepared by wet granulation method then press coated with hydroxypropyl cellulose (HPC) or Eudragit RSPO : RLPO mixture and further coated with Eudragit S-100 by dip immerse method. The in vitro drug release study was conducted in different dissolution media such as pH 1.2, 6.8, and 7.4 with or without rat caecal content to simulate GIT conditions. Surface morphology and cross-sectional view of the tablets were visualized by scanning electron microscopy (SEM). All prepared batches were in compliance with the pharmacopoeial standards. The tablets which are compression coated with HPC followed by Eudragit S-100 coated showed highest in vitro drug release of 98.10% in presence of rat caecal content. The SEM of tablets suggested that the number of pores got increased in pH 7.4 medium followed by dissolution of coating layer. The tablets coat erosion study suggested that the lag time depends upon the coating concentrations of polymers. A time-dependent hydrophilic polymer and pH sensitive polymer based press-coated tablets of naproxen were promising delivery for colon targeting.http://dx.doi.org/10.1155/2013/654829 |
| spellingShingle | Pooja Sharma Anuj Chawla Pravin Pawar Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen The Scientific World Journal |
| title | Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen |
| title_full | Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen |
| title_fullStr | Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen |
| title_full_unstemmed | Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen |
| title_short | Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen |
| title_sort | design development and optimization of polymeric based colonic drug delivery system of naproxen |
| url | http://dx.doi.org/10.1155/2013/654829 |
| work_keys_str_mv | AT poojasharma designdevelopmentandoptimizationofpolymericbasedcolonicdrugdeliverysystemofnaproxen AT anujchawla designdevelopmentandoptimizationofpolymericbasedcolonicdrugdeliverysystemofnaproxen AT pravinpawar designdevelopmentandoptimizationofpolymericbasedcolonicdrugdeliverysystemofnaproxen |