Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study
Objectives Central nervous system complications of acute pancreatitis (AP) can result in cerebral edema (CE). We assessed the risk of serious outcomes and health care features associated with CE in patients hospitalized with AP. Methods We conducted a retrospective cohort study using the National In...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605241311405 |
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| author | Muhammad Shahzil Ammad Javaid Chaudhary Saad Javaid Vishali Moond Gokturk Tepe Muhammad Saad Faisal Muhammad Ali Khaqan Anas Kutait |
| author_facet | Muhammad Shahzil Ammad Javaid Chaudhary Saad Javaid Vishali Moond Gokturk Tepe Muhammad Saad Faisal Muhammad Ali Khaqan Anas Kutait |
| author_sort | Muhammad Shahzil |
| collection | DOAJ |
| description | Objectives Central nervous system complications of acute pancreatitis (AP) can result in cerebral edema (CE). We assessed the risk of serious outcomes and health care features associated with CE in patients hospitalized with AP. Methods We conducted a retrospective cohort study using the National Inpatient Sample database. Patients were divided into the AP-CE group that developed CE and the AP-only group that did not. Outcome data were analyzed using Stata software. Results Among 543,464 patients hospitalized with AP, 220 (0.04%) developed CE. In multivariate analysis, primary outcomes included increased length of hospital stay (adjusted odds ratio [aOR] 10.1; 95% confidence interval [CI] 0.50–19.70), hospital charges (aOR USD 208,713; 95% CI 27,095–390,330), and risk of death (aOR 17.17; 95% CI 5.88–50.07) in the AP-CE group. Secondary outcomes showed patients with AP-CE had a significantly increased risk of serious complications, particularly cardiac arrest (aOR 64.24; 95% CI 24.27–170.02), and higher hospital resource utilization. Conclusion Patients with AP who develop CE face worse outcomes, including increased mortality risk, prolonged hospital stay, and greater resource utilization. Timely identification and effective management of CE in AP may reduce mortality and ease the health care burden associated with this neurological complication. |
| format | Article |
| id | doaj-art-ffca319fbffd46d8885708a999933aff |
| institution | Kabale University |
| issn | 1473-2300 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-ffca319fbffd46d8885708a999933aff2025-01-30T22:03:36ZengSAGE PublishingJournal of International Medical Research1473-23002025-01-015310.1177/03000605241311405Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort studyMuhammad ShahzilAmmad Javaid ChaudharySaad JavaidVishali MoondGokturk TepeMuhammad Saad FaisalMuhammad Ali KhaqanAnas KutaitObjectives Central nervous system complications of acute pancreatitis (AP) can result in cerebral edema (CE). We assessed the risk of serious outcomes and health care features associated with CE in patients hospitalized with AP. Methods We conducted a retrospective cohort study using the National Inpatient Sample database. Patients were divided into the AP-CE group that developed CE and the AP-only group that did not. Outcome data were analyzed using Stata software. Results Among 543,464 patients hospitalized with AP, 220 (0.04%) developed CE. In multivariate analysis, primary outcomes included increased length of hospital stay (adjusted odds ratio [aOR] 10.1; 95% confidence interval [CI] 0.50–19.70), hospital charges (aOR USD 208,713; 95% CI 27,095–390,330), and risk of death (aOR 17.17; 95% CI 5.88–50.07) in the AP-CE group. Secondary outcomes showed patients with AP-CE had a significantly increased risk of serious complications, particularly cardiac arrest (aOR 64.24; 95% CI 24.27–170.02), and higher hospital resource utilization. Conclusion Patients with AP who develop CE face worse outcomes, including increased mortality risk, prolonged hospital stay, and greater resource utilization. Timely identification and effective management of CE in AP may reduce mortality and ease the health care burden associated with this neurological complication.https://doi.org/10.1177/03000605241311405 |
| spellingShingle | Muhammad Shahzil Ammad Javaid Chaudhary Saad Javaid Vishali Moond Gokturk Tepe Muhammad Saad Faisal Muhammad Ali Khaqan Anas Kutait Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study Journal of International Medical Research |
| title | Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study |
| title_full | Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study |
| title_fullStr | Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study |
| title_full_unstemmed | Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study |
| title_short | Patient outcomes and health care resource utilization in acute pancreatitis-related central nervous system complications: insights from a national cohort study |
| title_sort | patient outcomes and health care resource utilization in acute pancreatitis related central nervous system complications insights from a national cohort study |
| url | https://doi.org/10.1177/03000605241311405 |
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