Cardiac Progenitor Cells and the Interplay with Their Microenvironment
The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these nic...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/7471582 |
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| _version_ | 1832545966331265024 |
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| author | Arianna Mauretti Sergio Spaans Noortje A. M. Bax Cecilia Sahlgren Carlijn V. C. Bouten |
| author_facet | Arianna Mauretti Sergio Spaans Noortje A. M. Bax Cecilia Sahlgren Carlijn V. C. Bouten |
| author_sort | Arianna Mauretti |
| collection | DOAJ |
| description | The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells, extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity. |
| format | Article |
| id | doaj-art-ffc6f737b5ea430e98a023e5158e28f7 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ffc6f737b5ea430e98a023e5158e28f72025-02-03T07:24:21ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/74715827471582Cardiac Progenitor Cells and the Interplay with Their MicroenvironmentArianna Mauretti0Sergio Spaans1Noortje A. M. Bax2Cecilia Sahlgren3Carlijn V. C. Bouten4Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsThe microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells, extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.http://dx.doi.org/10.1155/2017/7471582 |
| spellingShingle | Arianna Mauretti Sergio Spaans Noortje A. M. Bax Cecilia Sahlgren Carlijn V. C. Bouten Cardiac Progenitor Cells and the Interplay with Their Microenvironment Stem Cells International |
| title | Cardiac Progenitor Cells and the Interplay with Their Microenvironment |
| title_full | Cardiac Progenitor Cells and the Interplay with Their Microenvironment |
| title_fullStr | Cardiac Progenitor Cells and the Interplay with Their Microenvironment |
| title_full_unstemmed | Cardiac Progenitor Cells and the Interplay with Their Microenvironment |
| title_short | Cardiac Progenitor Cells and the Interplay with Their Microenvironment |
| title_sort | cardiac progenitor cells and the interplay with their microenvironment |
| url | http://dx.doi.org/10.1155/2017/7471582 |
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