GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons
Inhibitory interneurons comprise only about 20% of cortical neurons and thus constitute a clear minority compared to the vast number of excitatory projection neurons. They are, however, an influential minority with important roles in cortical maturation, function, and plasticity. In this paper, we w...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/892784 |
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| _version_ | 1849468224395018240 |
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| author | Konrad Lehmann André Steinecke Jürgen Bolz |
| author_facet | Konrad Lehmann André Steinecke Jürgen Bolz |
| author_sort | Konrad Lehmann |
| collection | DOAJ |
| description | Inhibitory interneurons comprise only about 20% of cortical neurons and thus constitute a clear minority compared to the vast number of excitatory projection neurons. They are, however, an influential minority with important roles in cortical maturation, function, and plasticity. In this paper, we will highlight the functional importance of cortical inhibition throughout brain development, starting with the embryonal formation of the cortex, proceeding by the regulation of sensory cortical plasticity in adulthood, and finishing with the GABA involvement in sensory information processing in old age. |
| format | Article |
| id | doaj-art-ffc6ae7d2ac748b4820a2ba4dfa8d0d1 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ffc6ae7d2ac748b4820a2ba4dfa8d0d12025-08-20T03:25:54ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/892784892784GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory InterneuronsKonrad Lehmann0André Steinecke1Jürgen Bolz2Institut für Allgemeine Zoologie und Tierphysiologie, Universität Jena, 07743 Jena, GermanyInstitut für Allgemeine Zoologie und Tierphysiologie, Universität Jena, 07743 Jena, GermanyInstitut für Allgemeine Zoologie und Tierphysiologie, Universität Jena, 07743 Jena, GermanyInhibitory interneurons comprise only about 20% of cortical neurons and thus constitute a clear minority compared to the vast number of excitatory projection neurons. They are, however, an influential minority with important roles in cortical maturation, function, and plasticity. In this paper, we will highlight the functional importance of cortical inhibition throughout brain development, starting with the embryonal formation of the cortex, proceeding by the regulation of sensory cortical plasticity in adulthood, and finishing with the GABA involvement in sensory information processing in old age.http://dx.doi.org/10.1155/2012/892784 |
| spellingShingle | Konrad Lehmann André Steinecke Jürgen Bolz GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons Neural Plasticity |
| title | GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons |
| title_full | GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons |
| title_fullStr | GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons |
| title_full_unstemmed | GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons |
| title_short | GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons |
| title_sort | gaba through the ages regulation of cortical function and plasticity by inhibitory interneurons |
| url | http://dx.doi.org/10.1155/2012/892784 |
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