Relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome-related hypertension
Abstract This study aimed to investigate the association of the vascular aging and left ventricular geometry in OSAHS-related hypertension population with good blood pressure control. A retrospective study was conducted at the Third Xiangya Hospital, collecting data from patients admitted between Au...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-89964-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850190844972236800 |
|---|---|
| author | Tao Liu Jianwei Zeng Xiexiong Zhao Ru Fu Liping Peng Xiaogang Li Weihong Jiang |
| author_facet | Tao Liu Jianwei Zeng Xiexiong Zhao Ru Fu Liping Peng Xiaogang Li Weihong Jiang |
| author_sort | Tao Liu |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the association of the vascular aging and left ventricular geometry in OSAHS-related hypertension population with good blood pressure control. A retrospective study was conducted at the Third Xiangya Hospital, collecting data from patients admitted between August 1, 2022, and January 1, 2024. Vascular aging parameters were collected, including ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and carotid intima-media thickness (cIMT). Left ventricular mass index (LVMI), relative wall thickness (RWT), left ventricular hypertrophy (LVH), and left ventricular concentric geometry (LVCG) were collected to assess left ventricular geometry patterns. Spearman correlation analysis, generalized linear regression, and logistic regression were used to assess the associations of the vascular aging and left ventricular geometry. A total of 238 patients were included. Significant positive correlations were found between baPWV and LVMI (Rs = 0.26, P < 0.001), baPWV and RWT (Rs = 0.37, P < 0.001), cIMT and LVMI (Rs = 0.24, P < 0.001), and cIMT and RWT (Rs = 0.34, P < 0.001). Generalized linear regression model indicated that both baPWV (β = 0.84, P = 0.01 for LVMI; β = 0.005, P < 0.001 for RWT) and cIMT (β = 27.54, P = 0.01 for LVMI; β = 0.13, P < 0.001 for RWT) were associated with LVMI and RWT, respectively. Logistic regression revealed that baPWV (OR = 1.08, 95%CI 1.02–1.15) and cIMT (OR = 1.30, 95%CI 1.06–1.60) were associated with LVH. baPWV (OR = 1.44, 95%CI 1.28–1.65) and cIMT (OR = 1.54, 95%CI 1.21–1.96) also showed associations with LVCG. Subgroup analyses based on gender and BMI suggested that the results were robust. This study showed that vascular aging parameters may be used to assess changes in left ventricular geometry of patients with OSAHS-related hypertension. |
| format | Article |
| id | doaj-art-ffc28a722b7b4e21b6efefb7f5e727cc |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ffc28a722b7b4e21b6efefb7f5e727cc2025-08-20T02:15:08ZengNature PortfolioScientific Reports2045-23222025-02-0115111110.1038/s41598-025-89964-4Relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome-related hypertensionTao Liu0Jianwei Zeng1Xiexiong Zhao2Ru Fu3Liping Peng4Xiaogang Li5Weihong Jiang6Department of Cardiovascular Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Third Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, The Third Xiangya Hospital, Central South UniversityAbstract This study aimed to investigate the association of the vascular aging and left ventricular geometry in OSAHS-related hypertension population with good blood pressure control. A retrospective study was conducted at the Third Xiangya Hospital, collecting data from patients admitted between August 1, 2022, and January 1, 2024. Vascular aging parameters were collected, including ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and carotid intima-media thickness (cIMT). Left ventricular mass index (LVMI), relative wall thickness (RWT), left ventricular hypertrophy (LVH), and left ventricular concentric geometry (LVCG) were collected to assess left ventricular geometry patterns. Spearman correlation analysis, generalized linear regression, and logistic regression were used to assess the associations of the vascular aging and left ventricular geometry. A total of 238 patients were included. Significant positive correlations were found between baPWV and LVMI (Rs = 0.26, P < 0.001), baPWV and RWT (Rs = 0.37, P < 0.001), cIMT and LVMI (Rs = 0.24, P < 0.001), and cIMT and RWT (Rs = 0.34, P < 0.001). Generalized linear regression model indicated that both baPWV (β = 0.84, P = 0.01 for LVMI; β = 0.005, P < 0.001 for RWT) and cIMT (β = 27.54, P = 0.01 for LVMI; β = 0.13, P < 0.001 for RWT) were associated with LVMI and RWT, respectively. Logistic regression revealed that baPWV (OR = 1.08, 95%CI 1.02–1.15) and cIMT (OR = 1.30, 95%CI 1.06–1.60) were associated with LVH. baPWV (OR = 1.44, 95%CI 1.28–1.65) and cIMT (OR = 1.54, 95%CI 1.21–1.96) also showed associations with LVCG. Subgroup analyses based on gender and BMI suggested that the results were robust. This study showed that vascular aging parameters may be used to assess changes in left ventricular geometry of patients with OSAHS-related hypertension.https://doi.org/10.1038/s41598-025-89964-4Obstructive sleep apnea hypopnea syndromeVascular agingLeft ventricular geometry |
| spellingShingle | Tao Liu Jianwei Zeng Xiexiong Zhao Ru Fu Liping Peng Xiaogang Li Weihong Jiang Relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome-related hypertension Scientific Reports Obstructive sleep apnea hypopnea syndrome Vascular aging Left ventricular geometry |
| title | Relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome-related hypertension |
| title_full | Relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome-related hypertension |
| title_fullStr | Relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome-related hypertension |
| title_full_unstemmed | Relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome-related hypertension |
| title_short | Relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome-related hypertension |
| title_sort | relationship between vascular aging and left ventricular geometry in patients with obstructive sleep apnea hypopnea syndrome related hypertension |
| topic | Obstructive sleep apnea hypopnea syndrome Vascular aging Left ventricular geometry |
| url | https://doi.org/10.1038/s41598-025-89964-4 |
| work_keys_str_mv | AT taoliu relationshipbetweenvascularagingandleftventriculargeometryinpatientswithobstructivesleepapneahypopneasyndromerelatedhypertension AT jianweizeng relationshipbetweenvascularagingandleftventriculargeometryinpatientswithobstructivesleepapneahypopneasyndromerelatedhypertension AT xiexiongzhao relationshipbetweenvascularagingandleftventriculargeometryinpatientswithobstructivesleepapneahypopneasyndromerelatedhypertension AT rufu relationshipbetweenvascularagingandleftventriculargeometryinpatientswithobstructivesleepapneahypopneasyndromerelatedhypertension AT lipingpeng relationshipbetweenvascularagingandleftventriculargeometryinpatientswithobstructivesleepapneahypopneasyndromerelatedhypertension AT xiaogangli relationshipbetweenvascularagingandleftventriculargeometryinpatientswithobstructivesleepapneahypopneasyndromerelatedhypertension AT weihongjiang relationshipbetweenvascularagingandleftventriculargeometryinpatientswithobstructivesleepapneahypopneasyndromerelatedhypertension |