Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma
Abstract Background Oral squamous cell carcinoma (OSCC) is the predominant form of head and neck cancer, often diagnosed at late stages, resulting in a poor prognosis. Recent studies indicate a potential association between OSCC and microbial presence. Microorganisms have been identified in various...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70209 |
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| author | Zhuoyan Luo Shiping Lv Fangzhi Lou Li Yan Jingyi Xu Ning Kang Yunmei Dong Xin Jin |
| author_facet | Zhuoyan Luo Shiping Lv Fangzhi Lou Li Yan Jingyi Xu Ning Kang Yunmei Dong Xin Jin |
| author_sort | Zhuoyan Luo |
| collection | DOAJ |
| description | Abstract Background Oral squamous cell carcinoma (OSCC) is the predominant form of head and neck cancer, often diagnosed at late stages, resulting in a poor prognosis. Recent studies indicate a potential association between OSCC and microbial presence. Microorganisms have been identified in various tumors and lesions, including OSCC and oral potentially malignant disorders (OPMDs). Intralesional microbiota are considered important components of the tumor microenvironment (TME) and may contribute to carcinogenesis. Methods Sources were collected through thorough searches of databases PubMed and Embase. The review focused on microbial characteristics, potential origins, and their impact on cancer progression. Results Bacteria display varying abundance and diversity throughout the stages of OSCC and OPMDs. Intraleisional bacteria may have diverse sources, including not only oral plaque and saliva but also potentially the gut. Intralesional bacteria have both pro‐carcinogenic and anti‐carcinogenic effects, affecting processes like cell proliferation, invasion, and immune response. Conclusions Intralesional microbiota are crucial in OSCC and OPMDs, influencing both disease progression and treatments. Despite their significance, challenges like inconsistent sampling and microbial identification remain. Future research is required to fully understand their role and improve clinical applications. |
| format | Article |
| id | doaj-art-ffc168f5e99b467082d62530ab8d41d5 |
| institution | DOAJ |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-ffc168f5e99b467082d62530ab8d41d52025-08-20T03:21:47ZengWileyCancer Medicine2045-76342024-09-011318n/an/a10.1002/cam4.70209Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinomaZhuoyan Luo0Shiping Lv1Fangzhi Lou2Li Yan3Jingyi Xu4Ning Kang5Yunmei Dong6Xin Jin7College of Stomatology Chongqing Medical University Chongqing ChinaCollege of Stomatology Chongqing Medical University Chongqing ChinaCollege of Stomatology Chongqing Medical University Chongqing ChinaCollege of Medical Informatics Chongqing Medical University Chongqing ChinaCollege of Stomatology Chongqing Medical University Chongqing ChinaCollege of Stomatology Chongqing Medical University Chongqing ChinaCollege of Stomatology Chongqing Medical University Chongqing ChinaCollege of Stomatology Chongqing Medical University Chongqing ChinaAbstract Background Oral squamous cell carcinoma (OSCC) is the predominant form of head and neck cancer, often diagnosed at late stages, resulting in a poor prognosis. Recent studies indicate a potential association between OSCC and microbial presence. Microorganisms have been identified in various tumors and lesions, including OSCC and oral potentially malignant disorders (OPMDs). Intralesional microbiota are considered important components of the tumor microenvironment (TME) and may contribute to carcinogenesis. Methods Sources were collected through thorough searches of databases PubMed and Embase. The review focused on microbial characteristics, potential origins, and their impact on cancer progression. Results Bacteria display varying abundance and diversity throughout the stages of OSCC and OPMDs. Intraleisional bacteria may have diverse sources, including not only oral plaque and saliva but also potentially the gut. Intralesional bacteria have both pro‐carcinogenic and anti‐carcinogenic effects, affecting processes like cell proliferation, invasion, and immune response. Conclusions Intralesional microbiota are crucial in OSCC and OPMDs, influencing both disease progression and treatments. Despite their significance, challenges like inconsistent sampling and microbial identification remain. Future research is required to fully understand their role and improve clinical applications.https://doi.org/10.1002/cam4.70209intralesional bacteriamicroenvironmentoral microbiotaoral potentially malignant disordersoral squamous cell carcinoma |
| spellingShingle | Zhuoyan Luo Shiping Lv Fangzhi Lou Li Yan Jingyi Xu Ning Kang Yunmei Dong Xin Jin Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma Cancer Medicine intralesional bacteria microenvironment oral microbiota oral potentially malignant disorders oral squamous cell carcinoma |
| title | Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma |
| title_full | Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma |
| title_fullStr | Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma |
| title_full_unstemmed | Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma |
| title_short | Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma |
| title_sort | roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma |
| topic | intralesional bacteria microenvironment oral microbiota oral potentially malignant disorders oral squamous cell carcinoma |
| url | https://doi.org/10.1002/cam4.70209 |
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