Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke
Background. Multimodal computed tomography (CT) guides decision-making regarding use of thrombolytic agents in acute ischemic stroke patients. However, postcontrast acute kidney injury (PC-AKI) is a potential adverse effect of the contrast media used, which may require hemodialysis and cause a longe...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2020/7182826 |
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| _version_ | 1832554058470129664 |
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| author | Sirichai Chusiri Aurauma Chutinet Nijasri Charnnarong Suwanwela Chankit Puttilerpong |
| author_facet | Sirichai Chusiri Aurauma Chutinet Nijasri Charnnarong Suwanwela Chankit Puttilerpong |
| author_sort | Sirichai Chusiri |
| collection | DOAJ |
| description | Background. Multimodal computed tomography (CT) guides decision-making regarding use of thrombolytic agents in acute ischemic stroke patients. However, postcontrast acute kidney injury (PC-AKI) is a potential adverse effect of the contrast media used, which may require hemodialysis and cause a longer hospital stay. The incidence and risk factors of PC-AKI in acute ischemic stroke patients, particularly in Thailand, remain unclear. Goal. We aimed at determining the incidence and risk factors of PC-AKI in patients with acute ischemic stroke undergoing multimodal CT. Methods. We conducted a retrospective review of Thai acute ischemic stroke patients admitted to the King Chulalongkorn Memorial Hospital between January 2014 and December 2017 who received multimodal CT and thrombolytic treatment with alteplase. Result. Overall, 109 patients were included for analysis; eight patients (7.3%) developed PC-AKI. Estimated glomerular filtration rate eGFR≤30 mL/min and mechanical thrombectomy were risk factors significantly associated with PC-AKI. Conclusion. The incidence of PC-AKI in a real practice setting did not differ from previous reports. Two factors were associated with PC-AKI, eGFR≤30 mL/min and mechanical thrombectomy. Patients without these risk factors may not need to wait for the results of renal function testing prior to multimodal CT. |
| format | Article |
| id | doaj-art-ffbf30f4aa0446f5a1c930bbd7121193 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-ffbf30f4aa0446f5a1c930bbd71211932025-02-03T05:52:30ZengWileyStroke Research and Treatment2090-81052042-00562020-01-01202010.1155/2020/71828267182826Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic StrokeSirichai Chusiri0Aurauma Chutinet1Nijasri Charnnarong Suwanwela2Chankit Puttilerpong3Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandDivision of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDivision of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandBackground. Multimodal computed tomography (CT) guides decision-making regarding use of thrombolytic agents in acute ischemic stroke patients. However, postcontrast acute kidney injury (PC-AKI) is a potential adverse effect of the contrast media used, which may require hemodialysis and cause a longer hospital stay. The incidence and risk factors of PC-AKI in acute ischemic stroke patients, particularly in Thailand, remain unclear. Goal. We aimed at determining the incidence and risk factors of PC-AKI in patients with acute ischemic stroke undergoing multimodal CT. Methods. We conducted a retrospective review of Thai acute ischemic stroke patients admitted to the King Chulalongkorn Memorial Hospital between January 2014 and December 2017 who received multimodal CT and thrombolytic treatment with alteplase. Result. Overall, 109 patients were included for analysis; eight patients (7.3%) developed PC-AKI. Estimated glomerular filtration rate eGFR≤30 mL/min and mechanical thrombectomy were risk factors significantly associated with PC-AKI. Conclusion. The incidence of PC-AKI in a real practice setting did not differ from previous reports. Two factors were associated with PC-AKI, eGFR≤30 mL/min and mechanical thrombectomy. Patients without these risk factors may not need to wait for the results of renal function testing prior to multimodal CT.http://dx.doi.org/10.1155/2020/7182826 |
| spellingShingle | Sirichai Chusiri Aurauma Chutinet Nijasri Charnnarong Suwanwela Chankit Puttilerpong Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke Stroke Research and Treatment |
| title | Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke |
| title_full | Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke |
| title_fullStr | Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke |
| title_full_unstemmed | Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke |
| title_short | Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke |
| title_sort | incidence and risk factors of postcontrast acute kidney injury in patients with acute ischemic stroke |
| url | http://dx.doi.org/10.1155/2020/7182826 |
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