A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset
Introduction. Childhood onset myasthenia gravis associated with anti-muscle-specific tyrosine kinase antibodies is very rare and atypical in presentation. Case report. As a baby, the pre-sented patient was choking and sleeping with open eyes. She had weak cry and breathing difficulties. In...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500039N.pdf |
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| author | Nikolić Ana V. Lavrnić Dragana V. Basta Ivana Z. Nikolić Dimitrije M. Apostolski Slobodan A. |
| author_facet | Nikolić Ana V. Lavrnić Dragana V. Basta Ivana Z. Nikolić Dimitrije M. Apostolski Slobodan A. |
| author_sort | Nikolić Ana V. |
| collection | DOAJ |
| description | Introduction. Childhood onset myasthenia gravis associated with
anti-muscle-specific tyrosine kinase antibodies is very rare and atypical in
presentation. Case report. As a baby, the pre-sented patient was choking and
sleeping with open eyes. She had weak cry and breathing difficulties. In
childhood, there were frequent falls and fluctuating swallowing difficulties.
At the age of 19 she was misdiagnosed with Miller Fisher syndrome due to the
presence of diplopia, ataxia and hyporeflexia with spontaneous recovery.
Repetitive nerve stimulation test was normal. Four years later, after several
relapses, there was significant decrement on facial muscles. Neostigmine test
was negative, provoking muscle fasciculations. Serum anti-muscle-specific
tyrosine kinase antibodies were positive. With cyclosporine therapy she
achieved the minimal manifestations status. Conclusion. The presented case
confirms that childhood onset myasthenia gravis associated with
anti-muscle-specific tyrosine kinase antibodies is often with atypical
presentation and spontaneous remissions, so it could be easily misdiagnosed. |
| format | Article |
| id | doaj-art-ffbae44ff2f04efabe4a0580ebf04b5f |
| institution | DOAJ |
| issn | 0042-8450 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-ffbae44ff2f04efabe4a0580ebf04b5f2025-08-20T03:06:13ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502015-01-0172763964110.2298/VSP131111039N0042-84501500039NA misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onsetNikolić Ana V.0Lavrnić Dragana V.1Basta Ivana Z.2Nikolić Dimitrije M.3Apostolski Slobodan A.4Clinical Center of Serbia, Neurology Clinic, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Neurology Clinic, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Neurology Clinic, Belgrade + Faculty of Medicine, BelgradeFaculty of Medicine, Belgrade + University Children’s Hospital, Neurology Department, BelgradPrivate Neurological Practice “Apostolski”, Belgrade, SerbiaIntroduction. Childhood onset myasthenia gravis associated with anti-muscle-specific tyrosine kinase antibodies is very rare and atypical in presentation. Case report. As a baby, the pre-sented patient was choking and sleeping with open eyes. She had weak cry and breathing difficulties. In childhood, there were frequent falls and fluctuating swallowing difficulties. At the age of 19 she was misdiagnosed with Miller Fisher syndrome due to the presence of diplopia, ataxia and hyporeflexia with spontaneous recovery. Repetitive nerve stimulation test was normal. Four years later, after several relapses, there was significant decrement on facial muscles. Neostigmine test was negative, provoking muscle fasciculations. Serum anti-muscle-specific tyrosine kinase antibodies were positive. With cyclosporine therapy she achieved the minimal manifestations status. Conclusion. The presented case confirms that childhood onset myasthenia gravis associated with anti-muscle-specific tyrosine kinase antibodies is often with atypical presentation and spontaneous remissions, so it could be easily misdiagnosed.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500039N.pdfmyasthenia gravischilddiagnosis, differentialantibodiesprotein-tyrosine kinases |
| spellingShingle | Nikolić Ana V. Lavrnić Dragana V. Basta Ivana Z. Nikolić Dimitrije M. Apostolski Slobodan A. A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset Vojnosanitetski Pregled myasthenia gravis child diagnosis, differential antibodies protein-tyrosine kinases |
| title | A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset |
| title_full | A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset |
| title_fullStr | A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset |
| title_full_unstemmed | A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset |
| title_short | A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset |
| title_sort | misdiagnosed myasthenia gravis with anti muscle specific tyrosine kinase antibodies with possible childhood onset |
| topic | myasthenia gravis child diagnosis, differential antibodies protein-tyrosine kinases |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500039N.pdf |
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