Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part I
In the pathogenesis of many inflammatory processes, an important role is played by a reaction cascade of various inflammasome types. The products of their activation are proinflammatory cytokines IL-1β and IL-18. These protein molecules can be secreted in two different ways as follows: by vesicular...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2024-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5986 |
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| author | A. A. Rubinstein A. A. Khodot P. V. Tirikova A. S. Golovkin I. V. Kudryavtsev E. V. Shlyakhto |
| author_facet | A. A. Rubinstein A. A. Khodot P. V. Tirikova A. S. Golovkin I. V. Kudryavtsev E. V. Shlyakhto |
| author_sort | A. A. Rubinstein |
| collection | DOAJ |
| description | In the pathogenesis of many inflammatory processes, an important role is played by a reaction cascade of various inflammasome types. The products of their activation are proinflammatory cytokines IL-1β and IL-18. These protein molecules can be secreted in two different ways as follows: by vesicular transport or by membrane pores, which subsequently leads to the secreting cell death. The role of inflammasome activation in cardiac tissue cells has not been sufficiently studied at present. However, there are some studies reflecting the association between the inflammasome cascade launch and cardiovascular diseases. Thus, inflammasome activation in cardiomyocytes can lead to electrolyte imbalance, which subsequently leads to ectopic foci in the cardiac tissue and cardiac arrhythmia. Triggering the inflammasome cascade in cardiac fibroblasts promotes fibrosis and myocardial tissue remodeling, which leads to disruption of heart functional activity. Inflammasome activation in coronary artery endothelial cells leads to endothelial dysfunction and atherogenesis. Thus, activation of various types of inflammasomes in cardiac tissue leads to cardiac pathology. |
| format | Article |
| id | doaj-art-ffb668e2fbee4b33b727d18107d72eaa |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-ffb668e2fbee4b33b727d18107d72eaa2025-08-20T03:01:27Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202024-12-012911S10.15829/1560-4071-2024-59864125Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part IA. A. Rubinstein0A. A. Khodot1P. V. Tirikova2A. S. Golovkin3I. V. Kudryavtsev4E. V. Shlyakhto5Almazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterIn the pathogenesis of many inflammatory processes, an important role is played by a reaction cascade of various inflammasome types. The products of their activation are proinflammatory cytokines IL-1β and IL-18. These protein molecules can be secreted in two different ways as follows: by vesicular transport or by membrane pores, which subsequently leads to the secreting cell death. The role of inflammasome activation in cardiac tissue cells has not been sufficiently studied at present. However, there are some studies reflecting the association between the inflammasome cascade launch and cardiovascular diseases. Thus, inflammasome activation in cardiomyocytes can lead to electrolyte imbalance, which subsequently leads to ectopic foci in the cardiac tissue and cardiac arrhythmia. Triggering the inflammasome cascade in cardiac fibroblasts promotes fibrosis and myocardial tissue remodeling, which leads to disruption of heart functional activity. Inflammasome activation in coronary artery endothelial cells leads to endothelial dysfunction and atherogenesis. Thus, activation of various types of inflammasomes in cardiac tissue leads to cardiac pathology.https://russjcardiol.elpub.ru/jour/article/view/5986inflammasomecaspasescardiomyocytesmyocardiumendothelial dysfunctionre-entry |
| spellingShingle | A. A. Rubinstein A. A. Khodot P. V. Tirikova A. S. Golovkin I. V. Kudryavtsev E. V. Shlyakhto Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part I Российский кардиологический журнал inflammasome caspases cardiomyocytes myocardium endothelial dysfunction re-entry |
| title | Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part I |
| title_full | Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part I |
| title_fullStr | Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part I |
| title_full_unstemmed | Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part I |
| title_short | Inflammasome - a new look at the therapy of cardiovascular diseases: a review. Part I |
| title_sort | inflammasome a new look at the therapy of cardiovascular diseases a review part i |
| topic | inflammasome caspases cardiomyocytes myocardium endothelial dysfunction re-entry |
| url | https://russjcardiol.elpub.ru/jour/article/view/5986 |
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