Nanozyme-based aptasensors for the detection of tumor biomarkers
Abstract A nanozyme-based aptasensor combines the unique properties of nanozymes with the specificity of aptamers for the detection of various biomolecules. Nanozymes are nanomaterials that possess enzyme-like properties, demonstrating substantial potential for enhancing the sensing capabilities of...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Journal of Biological Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13036-025-00485-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862019189637120 |
|---|---|
| author | Ke Wang Xiaogang Lin Xiao Lv Mingna Xie Jinyu Wu Jie Jayne Wu Yang Luo |
| author_facet | Ke Wang Xiaogang Lin Xiao Lv Mingna Xie Jinyu Wu Jie Jayne Wu Yang Luo |
| author_sort | Ke Wang |
| collection | DOAJ |
| description | Abstract A nanozyme-based aptasensor combines the unique properties of nanozymes with the specificity of aptamers for the detection of various biomolecules. Nanozymes are nanomaterials that possess enzyme-like properties, demonstrating substantial potential for enhancing the sensing capabilities of biosensors. In recent years, the incorporation of nanozymes into biosensors has opened new avenues for the detection of tumor biomarkers. The unique attributes of nanozymes and aptamers lead to biosensors characterized by high sensitivity, specificity, reproducibility and accuracy in analytical performance. This article reviews the research progress of nanozyme-based aptasensors in tumor biomarker detection over the past decade. We categorize these sensors based on their sensing modes and target types, and examine the properties and applications of the nanozymes employed in these devices, providing a thorough discussion of the strengths and weaknesses associated with each sensor type. Finally, the review highlights the strengths and challenges associated with nanozyme-based biosensors and envisions future developments and applications in this field. The objective is to provide insights for improving biosensor performance in tumor biomarker detection, thereby contributing to advancements in precision cancer diagnosis and treatment. |
| format | Article |
| id | doaj-art-ffb57323d5614a5885f8e9340caa2792 |
| institution | Kabale University |
| issn | 1754-1611 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biological Engineering |
| spelling | doaj-art-ffb57323d5614a5885f8e9340caa27922025-02-09T12:41:02ZengBMCJournal of Biological Engineering1754-16112025-02-0119111910.1186/s13036-025-00485-0Nanozyme-based aptasensors for the detection of tumor biomarkersKe Wang0Xiaogang Lin1Xiao Lv2Mingna Xie3Jinyu Wu4Jie Jayne Wu5Yang Luo6Key Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing UniversityKey Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing UniversityKey Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing UniversityKey Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing UniversityKey Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing UniversityDepartment of Electrical Engineering and Computer Science, The University of TennesseeChongqing General Hospital, Chongqing UniversityAbstract A nanozyme-based aptasensor combines the unique properties of nanozymes with the specificity of aptamers for the detection of various biomolecules. Nanozymes are nanomaterials that possess enzyme-like properties, demonstrating substantial potential for enhancing the sensing capabilities of biosensors. In recent years, the incorporation of nanozymes into biosensors has opened new avenues for the detection of tumor biomarkers. The unique attributes of nanozymes and aptamers lead to biosensors characterized by high sensitivity, specificity, reproducibility and accuracy in analytical performance. This article reviews the research progress of nanozyme-based aptasensors in tumor biomarker detection over the past decade. We categorize these sensors based on their sensing modes and target types, and examine the properties and applications of the nanozymes employed in these devices, providing a thorough discussion of the strengths and weaknesses associated with each sensor type. Finally, the review highlights the strengths and challenges associated with nanozyme-based biosensors and envisions future developments and applications in this field. The objective is to provide insights for improving biosensor performance in tumor biomarker detection, thereby contributing to advancements in precision cancer diagnosis and treatment.https://doi.org/10.1186/s13036-025-00485-0NanozymesAptamersTumor biomarkersBiosensorsPrecision diagnostic |
| spellingShingle | Ke Wang Xiaogang Lin Xiao Lv Mingna Xie Jinyu Wu Jie Jayne Wu Yang Luo Nanozyme-based aptasensors for the detection of tumor biomarkers Journal of Biological Engineering Nanozymes Aptamers Tumor biomarkers Biosensors Precision diagnostic |
| title | Nanozyme-based aptasensors for the detection of tumor biomarkers |
| title_full | Nanozyme-based aptasensors for the detection of tumor biomarkers |
| title_fullStr | Nanozyme-based aptasensors for the detection of tumor biomarkers |
| title_full_unstemmed | Nanozyme-based aptasensors for the detection of tumor biomarkers |
| title_short | Nanozyme-based aptasensors for the detection of tumor biomarkers |
| title_sort | nanozyme based aptasensors for the detection of tumor biomarkers |
| topic | Nanozymes Aptamers Tumor biomarkers Biosensors Precision diagnostic |
| url | https://doi.org/10.1186/s13036-025-00485-0 |
| work_keys_str_mv | AT kewang nanozymebasedaptasensorsforthedetectionoftumorbiomarkers AT xiaoganglin nanozymebasedaptasensorsforthedetectionoftumorbiomarkers AT xiaolv nanozymebasedaptasensorsforthedetectionoftumorbiomarkers AT mingnaxie nanozymebasedaptasensorsforthedetectionoftumorbiomarkers AT jinyuwu nanozymebasedaptasensorsforthedetectionoftumorbiomarkers AT jiejaynewu nanozymebasedaptasensorsforthedetectionoftumorbiomarkers AT yangluo nanozymebasedaptasensorsforthedetectionoftumorbiomarkers |