Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant Candida tropicalis

Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant Candida tropicalis

ABSTRACT Invasive candidiasis has emerged as a significant healthcare challenge, with a rising incidence rate attributed to the widespread use of organ transplantation, chemotherapy, immunosuppressants, and broad-spectrum antibiotics. The increasing prevalence of drug-resistant strains, particularly...

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Main Authors: Yun-Zhu Zhu, Xiang Li, Qing-Yue Zhang, Ning Yang, Ping Tian, Ding Zhang, Yi Yang, Liang Yu, Yan-Yan Liu, Ying Ye, Ya-Sheng Li, Jia-Bin Li
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
Candida tropicalis
fluconazole resistance
minocycline
synergistic effect
antifungal therapy
RNA sequencing
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03185-24
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