Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review
BackgroundCastleman disease (CD) is a relatively rare benign lymphoproliferative disorder of the lymphoid tissue. According to clinical manifestations, it is classified into two types: unicentric CD (UCD) and multicentric CD (MCD). Pathological subtypes include hyaline-vascular (HV), plasma cell (PC...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1563545/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850272169840345088 |
|---|---|
| author | Ting-Ting Sun Ting-Ting Sun Xue-Guo Sun Ti-Dong Shan Peng Zhao Yan-Yan Lu Qian Li Fu-Guo Liu |
| author_facet | Ting-Ting Sun Ting-Ting Sun Xue-Guo Sun Ti-Dong Shan Peng Zhao Yan-Yan Lu Qian Li Fu-Guo Liu |
| author_sort | Ting-Ting Sun |
| collection | DOAJ |
| description | BackgroundCastleman disease (CD) is a relatively rare benign lymphoproliferative disorder of the lymphoid tissue. According to clinical manifestations, it is classified into two types: unicentric CD (UCD) and multicentric CD (MCD). Pathological subtypes include hyaline-vascular (HV), plasma cell (PC), and mixed (MV). Gastrointestinal CD is extremely rare, and limited information is available regarding its clinical presentation and management.Case SummaryWe report a case of a patient who presented with paroxysmal epigastric pain for 4 years. Laboratory tests showed no remarkable abnormalities, whereas CT revealed endogenous occupancy on the side of the greater curvature of the stomach. Ultrasonographic endoscopy demonstrated hypoechoic, well-defined foci. The lesion initially suspected to be an inflammatory fibroma was subsequently pathologically confirmed as HV-UCD following endoscopic submucosal dissection. The lesion was completely resected, and the patient showed no signs of recurrence during 7 months of follow-up.ConclusionGastrointestinal CD is rare and should be differentiated from other occupying lesions. Its definitive diagnosis relies on histopathology. |
| format | Article |
| id | doaj-art-ffab38475dad457da3aa90c1d894184e |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-ffab38475dad457da3aa90c1d894184e2025-08-20T01:51:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15635451563545Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature reviewTing-Ting Sun0Ting-Ting Sun1Xue-Guo Sun2Ti-Dong Shan3Peng Zhao4Yan-Yan Lu5Qian Li6Fu-Guo Liu7Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaGastroenterology, Qingdao Medical College of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaBackgroundCastleman disease (CD) is a relatively rare benign lymphoproliferative disorder of the lymphoid tissue. According to clinical manifestations, it is classified into two types: unicentric CD (UCD) and multicentric CD (MCD). Pathological subtypes include hyaline-vascular (HV), plasma cell (PC), and mixed (MV). Gastrointestinal CD is extremely rare, and limited information is available regarding its clinical presentation and management.Case SummaryWe report a case of a patient who presented with paroxysmal epigastric pain for 4 years. Laboratory tests showed no remarkable abnormalities, whereas CT revealed endogenous occupancy on the side of the greater curvature of the stomach. Ultrasonographic endoscopy demonstrated hypoechoic, well-defined foci. The lesion initially suspected to be an inflammatory fibroma was subsequently pathologically confirmed as HV-UCD following endoscopic submucosal dissection. The lesion was completely resected, and the patient showed no signs of recurrence during 7 months of follow-up.ConclusionGastrointestinal CD is rare and should be differentiated from other occupying lesions. Its definitive diagnosis relies on histopathology.https://www.frontiersin.org/articles/10.3389/fonc.2025.1563545/fullunicentric Castleman diseasegastrointestinal tractCastleman diseaseendoscopic submucosal dissectionhistopathologycase report |
| spellingShingle | Ting-Ting Sun Ting-Ting Sun Xue-Guo Sun Ti-Dong Shan Peng Zhao Yan-Yan Lu Qian Li Fu-Guo Liu Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review Frontiers in Oncology unicentric Castleman disease gastrointestinal tract Castleman disease endoscopic submucosal dissection histopathology case report |
| title | Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review |
| title_full | Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review |
| title_fullStr | Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review |
| title_full_unstemmed | Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review |
| title_short | Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review |
| title_sort | castleman disease of stomach treated by endoscopic submucosal dissection a case report and literature review |
| topic | unicentric Castleman disease gastrointestinal tract Castleman disease endoscopic submucosal dissection histopathology case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1563545/full |
| work_keys_str_mv | AT tingtingsun castlemandiseaseofstomachtreatedbyendoscopicsubmucosaldissectionacasereportandliteraturereview AT tingtingsun castlemandiseaseofstomachtreatedbyendoscopicsubmucosaldissectionacasereportandliteraturereview AT xueguosun castlemandiseaseofstomachtreatedbyendoscopicsubmucosaldissectionacasereportandliteraturereview AT tidongshan castlemandiseaseofstomachtreatedbyendoscopicsubmucosaldissectionacasereportandliteraturereview AT pengzhao castlemandiseaseofstomachtreatedbyendoscopicsubmucosaldissectionacasereportandliteraturereview AT yanyanlu castlemandiseaseofstomachtreatedbyendoscopicsubmucosaldissectionacasereportandliteraturereview AT qianli castlemandiseaseofstomachtreatedbyendoscopicsubmucosaldissectionacasereportandliteraturereview AT fuguoliu castlemandiseaseofstomachtreatedbyendoscopicsubmucosaldissectionacasereportandliteraturereview |