PTGS2/GRP78 Activation Triggers Endoplasmic Reticulum Stress Leading to Lipid Metabolism Disruption and Cell Apoptosis, Exacerbating Damage in Bovine Mastitis

PTGS2/GRP78 Activation Triggers Endoplasmic Reticulum Stress Leading to Lipid Metabolism Disruption and Cell Apoptosis, Exacerbating Damage in Bovine Mastitis

Lipoteichoic acid (LTA), an organic acid of Gram-positive bacteria, is closely related to mastitis in dairy cows. This study evaluates the effect of LTA-induced endoplasmic reticulum stress (ER stress) in vitro using MAC-T (mammary epithelial cells) and in dairy cows with mastitis. LTA stimulation s...

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Bibliographic Details
Main Authors: Yan Chen, Bo Fang, Xian Liu, Wenkai Bai, Peiwen Liu, Zhiwei Duan, Ting Lu, Quanwei Zhang, Weitao Dong, Yong Zhang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
mastitis
lipoteichoic acid
endoplasmic reticulum stress
apoptosis
Online Access:https://www.mdpi.com/2218-273X/14/12/1533
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