Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes

Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes

Abstract Lactobacillus displacement from the vaginal microbiome associates with adverse health outcomes and is linked to increased risk of preterm birth. Glycans mediate bacterial adhesion events involved in colonisation and infection. Using customised glycan microarrays, we establish glycan interac...

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Main Authors: Virginia Tajadura-Ortega, Wengang Chai, Lauren A. Roberts, Yibing Zhang, Antonio Di Maio, Alexiane C. Decout, Benedita A. Pinheiro, Angelina S. Palma, Gian De Nicola, Lucia Riaposova, Belen Gimeno-Molina, Yun S. Lee, Hongzhi Cao, Vladimir Piskarev, Yukie Akune, Tiago R. D. Costa, Himani Amin, Lynne Sykes, Phillip R. Bennett, Julian R. Marchesi, Ten Feizi, Yan Liu, David A. MacIntyre
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60404-1
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