Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization
Background. Field cancerization is a phenomenon in which prolonged exposure to carcinogens induces changes throughout the epithelium leaving the field ready for the appearance of premalignant or malignant lesions. These alterations can promote the development of multiple carcinomas and explain the a...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/8428395 |
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| author | Carla Bento Nelem-Colturato Patrícia Maluf Cury Thiago Machado Pereira Isabelle Silva Cosso Kellin Pivato Luiz Evaristo Ricci Volpato Alvaro Henrique Borges |
| author_facet | Carla Bento Nelem-Colturato Patrícia Maluf Cury Thiago Machado Pereira Isabelle Silva Cosso Kellin Pivato Luiz Evaristo Ricci Volpato Alvaro Henrique Borges |
| author_sort | Carla Bento Nelem-Colturato |
| collection | DOAJ |
| description | Background. Field cancerization is a phenomenon in which prolonged exposure to carcinogens induces changes throughout the epithelium leaving the field ready for the appearance of premalignant or malignant lesions. These alterations can promote the development of multiple carcinomas and explain the appearance of recurrences and second primary tumors. The objective of this study was to report the case of a patient who developed six oral cavity tumors in five years of treatment and, also, demonstrate the immunohistochemical changes for p53 and Ki-67, routinely used to assess dysplasic regions. Case Report. When altered, p53 and Ki-67 suggest the presence of field cancers, an area with genetically altered cells, presenting a high risk of developing premalignant and malignant lesions. This phenomenon explains the recurrence of malignant neoplasms after tumor resections. Conclusion. In addition, early identification of potentially malignant lesions in cases of second primary tumors is essential for effective treatment and patient survival, which usually have an unwelcoming prognosis. |
| format | Article |
| id | doaj-art-ff9eded64fc04da58f437198ccc80167 |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-ff9eded64fc04da58f437198ccc801672025-08-20T02:22:50ZengWileyCase Reports in Pathology2090-67812090-679X2018-01-01201810.1155/2018/84283958428395Sextuple Tumors in Head and Neck Area: Evidence of Field CancerizationCarla Bento Nelem-Colturato0Patrícia Maluf Cury1Thiago Machado Pereira2Isabelle Silva Cosso3Kellin Pivato4Luiz Evaristo Ricci Volpato5Alvaro Henrique Borges6Health and Sports Sciences Center, Federal University of Acre, Rio Branco, Acre, BrazilDepartment of Pathology, The Ceres College School of Medicine (FACERES), São José do Rio Preto, São Paulo, BrazilDepartment of Oral Sciences, University of Cuiaba, Cuiaba, Mato Grosso, BrazilDepartment of Oral Sciences, University of Cuiaba, Cuiaba, Mato Grosso, BrazilDepartment of Oral Sciences, University of Cuiaba, Cuiaba, Mato Grosso, BrazilDepartment of Oral Sciences, University of Cuiaba, Cuiaba, Mato Grosso, BrazilDepartment of Oral Sciences, University of Cuiaba, Cuiaba, Mato Grosso, BrazilBackground. Field cancerization is a phenomenon in which prolonged exposure to carcinogens induces changes throughout the epithelium leaving the field ready for the appearance of premalignant or malignant lesions. These alterations can promote the development of multiple carcinomas and explain the appearance of recurrences and second primary tumors. The objective of this study was to report the case of a patient who developed six oral cavity tumors in five years of treatment and, also, demonstrate the immunohistochemical changes for p53 and Ki-67, routinely used to assess dysplasic regions. Case Report. When altered, p53 and Ki-67 suggest the presence of field cancers, an area with genetically altered cells, presenting a high risk of developing premalignant and malignant lesions. This phenomenon explains the recurrence of malignant neoplasms after tumor resections. Conclusion. In addition, early identification of potentially malignant lesions in cases of second primary tumors is essential for effective treatment and patient survival, which usually have an unwelcoming prognosis.http://dx.doi.org/10.1155/2018/8428395 |
| spellingShingle | Carla Bento Nelem-Colturato Patrícia Maluf Cury Thiago Machado Pereira Isabelle Silva Cosso Kellin Pivato Luiz Evaristo Ricci Volpato Alvaro Henrique Borges Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization Case Reports in Pathology |
| title | Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization |
| title_full | Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization |
| title_fullStr | Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization |
| title_full_unstemmed | Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization |
| title_short | Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization |
| title_sort | sextuple tumors in head and neck area evidence of field cancerization |
| url | http://dx.doi.org/10.1155/2018/8428395 |
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