PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study
Abstract Objective: The aim of this study was to assess the association between fish intake, n-3 PUFA, n-6 PUFA and risk of disabling dementia. Design: Prospective cohort. Setting: Municipalities within the Japan Public Health Centre-based Prospective Study. Participants: 43 651 participants...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | Public Health Nutrition |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1368980025000308/type/journal_article |
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| author | Sarah K Abe Manami Inoue Nobufumi Yasuda Kazumasa Yamagishi Shoichiro Tsugane Norie Sawada for the JPHC Study Group |
| author_facet | Sarah K Abe Manami Inoue Nobufumi Yasuda Kazumasa Yamagishi Shoichiro Tsugane Norie Sawada for the JPHC Study Group |
| author_sort | Sarah K Abe |
| collection | DOAJ |
| description |
Abstract
Objective:
The aim of this study was to assess the association between fish intake, n-3 PUFA, n-6 PUFA and risk of disabling dementia.
Design:
Prospective cohort.
Setting:
Municipalities within the Japan Public Health Centre-based Prospective Study.
Participants:
43 651 participants: (20 002 men and 23 649 women).
Results:
Exposure intake of fish, n-3 and n-6 PUFA was evaluated in 1995–1997. We defined disabling dementia cases as participants who were certified to receive disability care under the long-term-care insurance programme (2006–2016) in participating municipalities with a grade of activities of daily living related to dementia ≥ IIa on the dementia rating scale (range 0–IV and M). Cox proportional hazard models were applied to obtain hazard ratios (HR) and 95 % CI according to quartiles of exposures of interest. In the main analysis, we adjusted for age and area, smoking, BMI, alcohol and metabolic equivalent tasks. During 410 350 person-years of follow-up with an average follow-up of 9·4 years, 5278 cases of disabling dementia were diagnosed. Fish intake and most PUFA were not associated with the risk of disabling dementia in men. In women, n-6 PUFA showed a significant decreasing trend in risk the highest HR (95 % CI) compared with the lowest was 0·90 (0·81, 0·99) (P for trend = 0·024) and alpha-linolenic acid (ALA) was 0·91 (0·82, 1·00) (P for trend = 0·043).
Conclusions:
Our findings suggest no association with fish in general and only n-6 PUFA and ALA may be associated with a decreased risk of disabling dementia especially in women.
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| format | Article |
| id | doaj-art-ff9a239ae3784d53be6329bb2c62d591 |
| institution | DOAJ |
| issn | 1368-9800 1475-2727 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Public Health Nutrition |
| spelling | doaj-art-ff9a239ae3784d53be6329bb2c62d5912025-08-20T03:08:21ZengCambridge University PressPublic Health Nutrition1368-98001475-27272025-01-012810.1017/S1368980025000308PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia StudySarah K Abe0Manami Inoue1https://orcid.org/0000-0003-1276-2398Nobufumi Yasuda2Kazumasa Yamagishi3https://orcid.org/0000-0003-3301-5519Shoichiro Tsugane4Norie Sawada5for the JPHC Study GroupDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, JapanDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan Cancer Epidemiology, The University of Tokyo, Tokyo, Japan Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, JapanDepartment of Public Health, Kochi University Medical School, Kochi, JapanDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, JapanDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan International University of Health and Welfare Graduate School of Public Health, Tokyo, JapanDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan Abstract Objective: The aim of this study was to assess the association between fish intake, n-3 PUFA, n-6 PUFA and risk of disabling dementia. Design: Prospective cohort. Setting: Municipalities within the Japan Public Health Centre-based Prospective Study. Participants: 43 651 participants: (20 002 men and 23 649 women). Results: Exposure intake of fish, n-3 and n-6 PUFA was evaluated in 1995–1997. We defined disabling dementia cases as participants who were certified to receive disability care under the long-term-care insurance programme (2006–2016) in participating municipalities with a grade of activities of daily living related to dementia ≥ IIa on the dementia rating scale (range 0–IV and M). Cox proportional hazard models were applied to obtain hazard ratios (HR) and 95 % CI according to quartiles of exposures of interest. In the main analysis, we adjusted for age and area, smoking, BMI, alcohol and metabolic equivalent tasks. During 410 350 person-years of follow-up with an average follow-up of 9·4 years, 5278 cases of disabling dementia were diagnosed. Fish intake and most PUFA were not associated with the risk of disabling dementia in men. In women, n-6 PUFA showed a significant decreasing trend in risk the highest HR (95 % CI) compared with the lowest was 0·90 (0·81, 0·99) (P for trend = 0·024) and alpha-linolenic acid (ALA) was 0·91 (0·82, 1·00) (P for trend = 0·043). Conclusions: Our findings suggest no association with fish in general and only n-6 PUFA and ALA may be associated with a decreased risk of disabling dementia especially in women. https://www.cambridge.org/core/product/identifier/S1368980025000308/type/journal_articleFishPUFADementiaJapanCohort |
| spellingShingle | Sarah K Abe Manami Inoue Nobufumi Yasuda Kazumasa Yamagishi Shoichiro Tsugane Norie Sawada for the JPHC Study Group PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study Public Health Nutrition Fish PUFA Dementia Japan Cohort |
| title | PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study |
| title_full | PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study |
| title_fullStr | PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study |
| title_full_unstemmed | PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study |
| title_short | PUFA, fish intake and risk of disabling dementia in Japan: the Japan Public Health Centre Disabling Dementia Study |
| title_sort | pufa fish intake and risk of disabling dementia in japan the japan public health centre disabling dementia study |
| topic | Fish PUFA Dementia Japan Cohort |
| url | https://www.cambridge.org/core/product/identifier/S1368980025000308/type/journal_article |
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