Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial.

Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial.

<h4>Background</h4>Wound healing is impaired in diabetes mellitus, but the mechanisms involved in this process are virtually unknown. Proteins belonging to the insulin signaling pathway respond to insulin in the skin of rats.<h4>Objective</h4>The purpose of this study was to...

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Main Authors: Maria H M Lima, Andréa M Caricilli, Lélia L de Abreu, Eliana P Araújo, Fabiana F Pelegrinelli, Ana C P Thirone, Daniela M Tsukumo, Ana Flávia M Pessoa, Marinilce F dos Santos, Maria A de Moraes, José B C Carvalheira, Lício A Velloso, Mario J A Saad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036974&type=printable
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