Emergence of transferable tigecycline and eravacycline resistance gene tet(X4) in Escherichia coli isolates from Iran

Emergence of transferable tigecycline and eravacycline resistance gene tet(X4) in Escherichia coli isolates from Iran

Abstract Tigecycline (TGC) and eravacycline (ERV) are critical last-resort antibiotics used to treat complicated infections caused by extensively drug-resistant Gram-negative bacteria particularly carbapenem- and colistin-resistant Enterobacterales. The recent emergence of plasmid-mediated TGC resis...

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Bibliographic Details
Main Authors: Mehri Haeili, Mahdi Aghajanzadeh, Kiarash Moghaddasi, Maryam Omrani, Arash Ghodousi, Daniela Maria Cirillo
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Tigecycline resistance
tet(X4)
Escherichia coli
Plasmid
Fecal samples
Online Access:https://doi.org/10.1038/s41598-025-98206-6
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