Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders
Abstract Poor introspective accuracy (IA), defined as inaccurate judgments of one’s abilities and performance, is a strong and independent predictor of functional impairment in people with psychotic disorders. However, there are currently no treatments that directly target IA in this population as a...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | NPP-Digital Psychiatry and Neuroscience |
| Online Access: | https://doi.org/10.1038/s44277-024-00024-7 |
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| author | Sarah A. Berretta Nicole Abaya Emma Parrish Lauren E. McBride Raeanne C. Moore Robert Ackerman Philip D. Harvey Amy E. Pinkham Colin A. Depp |
| author_facet | Sarah A. Berretta Nicole Abaya Emma Parrish Lauren E. McBride Raeanne C. Moore Robert Ackerman Philip D. Harvey Amy E. Pinkham Colin A. Depp |
| author_sort | Sarah A. Berretta |
| collection | DOAJ |
| description | Abstract Poor introspective accuracy (IA), defined as inaccurate judgments of one’s abilities and performance, is a strong and independent predictor of functional impairment in people with psychotic disorders. However, there are currently no treatments that directly target IA in this population as a primary outcome. We describe a protocol for a clinical trial to test a newly developed blended digital intervention, Improving Thinking through Everyday SelfAssessment Training (iTEST), aimed at improving IA in people with psychotic disorders to improve functional outcomes. iTEST involves daily training consisting of feedback on IA in mobile cognitive tests, coupled with individual coaching that applies improved IA to participant-identified recovery goals. Following the NIMH experimental therapeutics paradigm, the first step in the evaluation of iTEST is an open trial in 60 individuals with psychotic disorders to assess 1) feasibility and acceptability, and 2) whether the intervention leads to clinically significant improvement in an objective target: IA on trained tasks along with transfer to an untrained task-based measure of IA. After programming of the mobile intervention and the creation of treatment manuals, enrollment for an open trial started in November 2023 and will be completed by April 2025. If effective, iTEST could be integrated with cognitive training and other rehabilitative interventions to boost the impact on functional outcomes. Trial registration: ClinicalTrials.gov NCT05899348. |
| format | Article |
| id | doaj-art-ff9668d8315246b5a2bf2cea33fc8a28 |
| institution | OA Journals |
| issn | 2948-1570 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | NPP-Digital Psychiatry and Neuroscience |
| spelling | doaj-art-ff9668d8315246b5a2bf2cea33fc8a282025-08-20T02:13:02ZengSpringerNPP-Digital Psychiatry and Neuroscience2948-15702025-02-01311810.1038/s44277-024-00024-7Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disordersSarah A. Berretta0Nicole Abaya1Emma Parrish2Lauren E. McBride3Raeanne C. Moore4Robert Ackerman5Philip D. Harvey6Amy E. Pinkham7Colin A. Depp8School of Behavioral and Brain Sciences, The University of Texas at DallasDepartment of Psychiatry, University of California San DiegoSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical PsychologySan Diego State University/University of California San Diego Joint Doctoral Program in Clinical PsychologyDepartment of Psychiatry, University of California San DiegoSchool of Behavioral and Brain Sciences, The University of Texas at DallasResearch Service, Bruce W Cater Miami VA Healthcare SystemSchool of Behavioral and Brain Sciences, The University of Texas at DallasDepartment of Psychiatry, University of California San DiegoAbstract Poor introspective accuracy (IA), defined as inaccurate judgments of one’s abilities and performance, is a strong and independent predictor of functional impairment in people with psychotic disorders. However, there are currently no treatments that directly target IA in this population as a primary outcome. We describe a protocol for a clinical trial to test a newly developed blended digital intervention, Improving Thinking through Everyday SelfAssessment Training (iTEST), aimed at improving IA in people with psychotic disorders to improve functional outcomes. iTEST involves daily training consisting of feedback on IA in mobile cognitive tests, coupled with individual coaching that applies improved IA to participant-identified recovery goals. Following the NIMH experimental therapeutics paradigm, the first step in the evaluation of iTEST is an open trial in 60 individuals with psychotic disorders to assess 1) feasibility and acceptability, and 2) whether the intervention leads to clinically significant improvement in an objective target: IA on trained tasks along with transfer to an untrained task-based measure of IA. After programming of the mobile intervention and the creation of treatment manuals, enrollment for an open trial started in November 2023 and will be completed by April 2025. If effective, iTEST could be integrated with cognitive training and other rehabilitative interventions to boost the impact on functional outcomes. Trial registration: ClinicalTrials.gov NCT05899348.https://doi.org/10.1038/s44277-024-00024-7 |
| spellingShingle | Sarah A. Berretta Nicole Abaya Emma Parrish Lauren E. McBride Raeanne C. Moore Robert Ackerman Philip D. Harvey Amy E. Pinkham Colin A. Depp Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders NPP-Digital Psychiatry and Neuroscience |
| title | Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders |
| title_full | Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders |
| title_fullStr | Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders |
| title_full_unstemmed | Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders |
| title_short | Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders |
| title_sort | protocol for evaluation of itest a novel blended intervention to enhance introspective accuracy in psychotic disorders |
| url | https://doi.org/10.1038/s44277-024-00024-7 |
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